Radiation burn "innovating therapeutic approach"

被引：7
作者：
Bey, E. [1 ]
Doucet, C. [2 ]
Duhamel, P. [1 ]
Brachet, M. [1 ]
Prat, M. [2 ]
Bargues, L. [3 ]
Amabile, J. -C. [4 ]
Gourmelon, P. [5 ]
Lataillade, J. -J. [2 ]
机构：
[1] Serv Chirurg Plast HIA Percy, F-94141 Clamart, France
[2] Ctr Transfus Sanguine Armees HIA Percy, F-94141 Clamart, France
[3] Ctr Traitement Brules HIA Percy, F-94141 Clamart, France
[4] Serv Protect Radiol Armees HIA Percy, F-94141 Clamart, France
[5] Inst Radioprotect & Surete Nucl, F-92262 Fontenay Aux Roses, France
来源：
ANNALES DE CHIRURGIE PLASTIQUE ESTHETIQUE | 2010年 / 55卷 / 05期
关键词：
Radiation burn; Dosimetry; Surgery; Cellular therapy; Mesenchymal stem cells; MESENCHYMAL STEM-CELLS; PLATELET-RICH PLASMA; EX-VIVO EXPANSION; STROMAL CELLS; MARROW; SERUM; ENHANCEMENT; DISEASE; SURGERY; ORGANS;
D O I：
10.1016/j.anplas.2010.07.009
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Radiation burn is a determinist effect of localized irradiation. The lesion is in good correlation with absorbed dose. Radiation burn is different from thermal burn. The evolution is spatiotemporal unpredictable with successive inflammatory waves and recurrence of necrosis. The conventional surgical treatment is rarely efficient because each surgical operative act seems to stimulate the inflammatory waves and fibro-necrosis process. The lesion can escape to this conventional surgical treatment. The new therapeutic approach combines surgery and cellular therapy with local administration of autologous mesenchymal stem cells. From 5 years, cell therapy have been an adjuvant treatment of surgery. This association is a therapeutic innovation, it's now the recommendation for conservative surgery of this very serious radiation burn. (C) 2010 Publie par Elsevier Masson SAS.
引用
收藏
页码：354 / 362
页数：9
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