Wound healing properties of triple cross-linked poly (vinyl alcohol)/ methacrylate kappa-carrageenan/chitooligosaccharide hydrogel

被引：69

作者：

Chandika, Pathum ^{[1
,2
]}

Kim, Min-Sung ^{[1
,2
]}

Khan, Fazlurrahman ^{[3
]}

Kim, Young-Mog ^{[3
,4
]}

Heo, Seong-Yeong ^{[3
]}

Oh, Gun-Woo ^{[3
]}

Kim, Nam Gyun ^{[1
,2
]}

Jung, Won-Kyo ^{[1
,2
,3
]}

机构：

[1] Pukyong Natl Univ, Dept Biomed Engn, Busan 48513, South Korea

[2] Pukyong Natl Univ, New Senior Healthcare Innovat Ctr BK21 Plus, Busan 48513, South Korea

[3] Pukyong Natl Univ, Res Ctr Marine Integrated Bion Technol, Busan 48513, South Korea

[4] Pukyong Natl Univ, Dept Food Sci & Technol, Busan 48513, South Korea

来源：

CARBOHYDRATE POLYMERS | 2021年 / 269卷

基金：

新加坡国家研究基金会;

关键词：

PVA; Methacrylate kappa-carrageenan; Chitooligosaccharide; Hydrogel wound dressing; Wound healing; CARRAGEENAN-BASED HYDROGELS; DELIVERY;

D O I：

10.1016/j.carbpol.2021.118272

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

To develop an effective and mechanically robust wound dressing, a poly (vinyl alcohol) (PVA)/methacrylate kappa-carrageenan (ic-CaMA) composite hydrogel encapsulated with a chitooligosaccharide (COS) was prepared in a cassette via repeated freeze/thaw cycles, photo-crosslinking, and chemical cross-linking. The chemical, physical, mechanical, in vitro biocompatibility, in vivo wound-healing properties, and antibacterial activity of triple-crosslinked hydrogel were subsequently characterized. The results showed that the PVA/ic-CaMA/COS (PicCaC) hydrogel had a uniformly thick, highly porous three-dimensional architecture with uniformly distributed pores, a high fluid absorption, and retention capacity without disturbing its mechanical stability, and good in vitro biocompatibility. Macroscopic images from the full-thickness skin wound model revealed that the wounds dressed with the proposed Pic-CaC hydrogel were completely healed by day 14, while the histomorphological results confirmed full re-epithelization and rapid skin-tissue remodeling. This study thus indicates that the composite Pic-CaC hydrogel has significant potential for use as a wound dressing.

引用

页数：11

共 26 条

[1] Development of a polyvinyl alcohol/sodium alginate hydrogel-based scaffold incorporating bFGF-encapsulated microspheres for accelerated wound healing [J].