The ubiquitin proteasome pathway in neuropsychiatric disorders

被引：23

作者：

Cheon, Solmi ^{[1
]}

Dean, Milan ^{[1
]}

Chahrour, Maria ^{[1
,2
,3
]}

机构：

[1] Univ Texas Southwestern Med Ctr Dallas, Eugene McDermott Ctr Human Growth & Dev, Dallas, TX 75390 USA

[2] Univ Texas Southwestern Med Ctr Dallas, Dept Neurosci, 5323 Harry Hines Blvd,NB10-104, Dallas, TX 75390 USA

[3] Univ Texas Southwestern Med Ctr Dallas, Dept Psychiat, 5323 Harry Hines Blvd,NB10-104, Dallas, TX 75390 USA

来源：

NEUROBIOLOGY OF LEARNING AND MEMORY | 2019年 / 165卷

关键词：

Proteasome pathway; Ubiquitin; Autism spectrum disorder; Neuropsychiatric disorders; DEFICIT HYPERACTIVITY DISORDER; INTELLECTUAL-DISABILITY; GENE-EXPRESSION; ANGELMAN SYNDROME; BIPOLAR DISORDER; OXIDATIVE STRESS; DEVELOPMENTAL DELAY; PROTEIN NETWORK; NEURONAL CELLS; LIGASE UBE3B;

D O I：

10.1016/j.nlm.2018.01.012

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The ubiquitin proteasome system (UPS) is a highly conserved pathway that tightly regulates protein tumover in cells. This process is integral to neuronal development, differentiation, and function. Several members of the UPS are disrupted in neuropsychiatric disorders, highlighting the importance of this pathway in brain development and function. In this review, we discuss some of these pathway members, the molecular processes they regulate, and the potential for targeting the UPS in an effort to develop therapeutic strategies in neuropsychiatric and neurodevelopmental disorders.

引用

页数：7

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