The ubiquitin proteasome pathway in neuropsychiatric disorders

被引：23

作者：

Cheon, Solmi ^{[1
]}

Dean, Milan ^{[1
]}

Chahrour, Maria ^{[1
,2
,3
]}

机构：

[1] Univ Texas Southwestern Med Ctr Dallas, Eugene McDermott Ctr Human Growth & Dev, Dallas, TX 75390 USA

[2] Univ Texas Southwestern Med Ctr Dallas, Dept Neurosci, 5323 Harry Hines Blvd,NB10-104, Dallas, TX 75390 USA

[3] Univ Texas Southwestern Med Ctr Dallas, Dept Psychiat, 5323 Harry Hines Blvd,NB10-104, Dallas, TX 75390 USA

来源：

NEUROBIOLOGY OF LEARNING AND MEMORY | 2019年 / 165卷

关键词：

Proteasome pathway; Ubiquitin; Autism spectrum disorder; Neuropsychiatric disorders; DEFICIT HYPERACTIVITY DISORDER; INTELLECTUAL-DISABILITY; GENE-EXPRESSION; ANGELMAN SYNDROME; BIPOLAR DISORDER; OXIDATIVE STRESS; DEVELOPMENTAL DELAY; PROTEIN NETWORK; NEURONAL CELLS; LIGASE UBE3B;

D O I：

10.1016/j.nlm.2018.01.012

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The ubiquitin proteasome system (UPS) is a highly conserved pathway that tightly regulates protein tumover in cells. This process is integral to neuronal development, differentiation, and function. Several members of the UPS are disrupted in neuropsychiatric disorders, highlighting the importance of this pathway in brain development and function. In this review, we discuss some of these pathway members, the molecular processes they regulate, and the potential for targeting the UPS in an effort to develop therapeutic strategies in neuropsychiatric and neurodevelopmental disorders.

引用

页数：7

共 97 条

[1] Deficient hippocampal neuron expression of proteasome, ubiquitin, and mitochondrial genes in multiple schizophrenia cohorts [J].

Altar, CA ;

Jurata, LW ;

Charles, V ;

Lemire, A ;

Liu, P ;

Bukhman, Y ;

Young, TA ;

Bullard, J ;

Yokoe, H ;

Webster, MJ ;

Knable, MB ;

Brockman, JA .

BIOLOGICAL PSYCHIATRY, 2005, 58 (02) :85-96

[2] Population-Specific Haplotype Association of the Postsynaptic Density Gene DLG4 with Schizophrenia, in Family-Based Association Studies [J].

Balan, Shabeesh ;

Yamada, Kazuo ;

Hattori, Eiji ;

Iwayama, Yoshimi ;

Toyota, Tomoko ;

Ohnishi, Tetsuo ;

Maekawa, Motoko ;

Toyoshima, Manabu ;

Iwata, Yasuhide ;

Suzuki, Katsuaki ;

Kikuchi, Mitsuru ;

Yoshikawa, Takeo .

PLOS ONE, 2013, 8 (07)

[3] Deficiency for the Ubiquitin Ligase UBE3B in a Blepharophimosis-Ptosis-Intellectual-Disability Syndrome [J].

Basel-Vanagaite, Lina ;

Dallapiccola, Bruno ;

Ramirez-Solis, Ramiro ;

Segref, Alexandra ;

Thiele, Holger ;

Edwards, Andrew ;

Arends, Mark J. ;

Miro, Xavier ;

White, Jacqueline K. ;

Desir, Julie ;

Abramowicz, Marc ;

Dentici, Maria Lisa ;

Lepri, Francesca ;

Hofmann, Kay ;

Har-Zahav, Adi ;

Ryder, Edward ;

Karp, Natasha A. ;

Estabel, Jeanne ;

Gerdin, Anna-Karin B. ;

Podrini, Christine ;

Ingham, Neil J. ;

Altmueller, Janine ;

Nuernberg, Gudrun ;

Frommolt, Peter ;

Abdelhak, Sonia ;

Pasmanik-Chor, Metsada ;

Konen, Osnat ;

Kelley, Richard I. ;

Shohat, Mordechai ;

Nuernberg, Peter ;

Flint, Jonathan ;

Steel, Karen P. ;

Hoppe, Thorsten ;

Kubisch, Christian ;

Adams, David J. ;

Borck, Guntram .

AMERICAN JOURNAL OF HUMAN GENETICS, 2012, 91 (06) :998-1010

[4] Adult neuron survival strategies - Slamming on the brakes [J].

Benn, SC ;

Woolf, CJ .

NATURE REVIEWS NEUROSCIENCE, 2004, 5 (09) :686-700

[5] De novo missense variants in HECW2 are associated with neurodevelopmental delay and hypotonia [J].

Berko, Esther R. ;

Cho, Megan T. ;

Eng, Christine ;

Shao, Yunru ;

Sweetser, David A. ;

Waxler, Jessica ;

Robin, Nathaniel H. ;

Brewer, Fallon ;

Donkervoort, Sandra ;

Mohassel, Payam ;

Bonnemann, Carsten G. ;

Bialer, Martin ;

Moore, Christine ;

Wolfe, Lynne A. ;

Tifft, Cynthia J. ;

Shen, Yufeng ;

Retterer, Kyle ;

Millan, Francisca ;

Chung, Wendy K. .

JOURNAL OF MEDICAL GENETICS, 2017, 54 (02) :93-99

[6] New insights into ubiquitin E3 ligase mechanism [J].

Berndsen, Christopher E. ;

Wolberger, Cynthia .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2014, 21 (04) :301-307

[7]

Boskovic M, 2011, CURR NEUROPHARMACOL, V9, P301, DOI 10.2174/157015911795596595

[8] Preliminary Evidence of Ubiquitin Proteasome System Dysregulation in Schizophrenia and Bipolar Disorder: Convergent Pathway Analysis Findings from Two Independent Samples [J].

Bousman, Chad A. ;

Chana, Gursharan ;

Glatt, Stephen J. ;

Chandler, Sharon D. ;

Lucero, Ginger R. ;

Tatro, Erick ;

May, Todd ;

Lohr, James B. ;

Kremen, William S. ;

Tsuang, Ming T. ;

Everall, Ian P. .

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2010, 153B (02) :494-502

[9] An essential role for UBE2A/HR6A in learning and memory and mGLUR-dependent long-term depression [J].

Bruinsma, Caroline F. ;

Savelberg, Sanne M. C. ;

Kool, Martijn J. ;

Jolfaei, Mehrnoush Aghadavoud ;

Van Woerden, Geeske M. ;

Baarends, Willy M. ;

Elgersma, Ype .

HUMAN MOLECULAR GENETICS, 2016, 25 (01) :1-8

[10] Clinical Overview of MDM2/X-Targeted Therapies [J].

Burgess, Andrew ;

Chia, Kee Ming ;

Haupt, Sue ;

Thomas, David ;

Haupt, Ygal ;

Lim, Elgene .

FRONTIERS IN ONCOLOGY, 2016, 6

← 1 2 3 4 5 6 7 8 9 10 →