Tetrazine-trans-cyclooctene ligation for the rapid construction of 18F labeled probes

被引：155

作者：

Li, Zibo ^{[1
]}

Cai, Hancheng ^{[1
]}

Hassink, Matthew ^{[2
]}

Blackman, Melissa L. ^{[2
]}

Brown, Richard C. D. ^{[3
]}

Conti, Peter S. ^{[1
]}

Fox, Joseph M. ^{[2
]}

机构：

[1] Univ So Calif, Dept Radiol, Mol Imaging Ctr, Los Angeles, CA 90033 USA

[2] Univ Delaware, Dept Chem & Biochem, Brown Labs, Newark, DE 19803 USA

[3] Univ Southampton, Sch Chem, Southampton SO17 1BJ, Hants, England

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 42期

基金：

美国国家科学基金会;

关键词：

CLICK CHEMISTRY; PEPTIDES; PET;

D O I：

10.1039/c0cc03078c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A radiolabeling method for bioconjugation based on the Diels-Alder reaction between 3,6-diaryl-s-tetrazines and an F-18-labeled trans-cyclooctene is described. The reaction proceeds with exceptionally fast rates, making it an effective conjugation method within seconds at low micromolar concentrations.

引用

页码：8043 / 8045

页数：3

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