The thrombin-fibrinogen interaction

被引：73
作者：
Scheraga, HA [1 ]
机构：
[1] Cornell Univ, Baker Lab Chem, Ithaca, NY 14853 USA
来源：
BIOPHYSICAL CHEMISTRY | 2004年 / 112卷 / 2-3期
关键词：
thrombin; fibrinogen; fibrin; fibrinopeptides; fibrin clot; enzymatic hydrolysis; protein-protein interactions;
D O I：
10.1016/j.bpc.2004.07.011
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The thrombin-catalyzed conversion of fibrinogen (F) to fibrin consists of three reversible steps, with thrombin (T) being involved in only the first step which is a limited proteolysis to release fibrinopeptides (FpA and FpB) from fibrinogen to produce fibrin monomer. In the second step, fibrin monomers form intermediate polymers through noncovalent interactions. In the third step, the intermediate polymers aggregate to form the fibrin clot. The molecular mechanisms of the first two steps are elucidated. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：117 / 130
页数：14
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