Scalusamides A-C, new pyrrolidine alkaloids from the marine-derived fungus Penicillium citrinum

被引：56

作者：

Tsuda, M

Sasaki, M

Mugishima, T

Komatsu, K

Sone, T

Tanaka, M

Mikami, Y

Kobayashi, J ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan

[2] Hokkaido Univ, Grad Sch Agr, Sapporo, Hokkaido 0608589, Japan

[3] Chiba Univ, Pathogen Fungi & Microbial Toxicoses Res Ctr, Chiba 2600856, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2005年 / 68卷 / 02期

关键词：

D O I：

10.1021/np049661q

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new pyrrolidine alkaloids, scalusamides A-C (1-3), were isolated from the cultured broth of the fungus Penicillium citrinum, which was separated from the gastrointestine of a marine fish, and the structures were elucidated by spectroscopic data. The absolute stereochemistry of C-2 in the pyrrolidine unit was determined by HPLC analysis of a Marfey's derivative of the hydrolysate of 1, while that of 2 and 3 was assigned by comparison of spectroscopic data of 3 and reductive products of 1 and 2. On the other hand, each of 1-3 was found to be a mixture of epimers at C-7. Scalusamide A (1) exhibited antifungal and antibacterial activities.

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页码：273 / 276

页数：4

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