Opioids in rheumatic diseases

被引：16

作者：

Lang, L. J. ^{[1
]}

Pierer, M. ^{[2
]}

Stein, C. ^{[1
]}

Baerwald, C. ^{[2
]}

机构：

[1] Free Univ Berlin, Klin Anasthesiol & Operat Intens Med, Charite Campus Benjamin Franklin, D-12200 Berlin, Germany

[2] Univ Klinikum, Dept Innere Med, Sekt Rheumatol, Leipzig, Germany

来源：

NEUROENDOCRINE IMMUNOLOGY IN RHEUMATIC DISEASES: TRANSLATION FROM BASICS TO CLINICS | 2010年 / 1193卷

关键词：

opioids; musculoskeletal pain; rheumatoid arthritis; osteoarthritis; peripheral opioid effects; CHRONIC NONMALIGNANT PAIN; CHRONIC NONCANCER PAIN; MECHANISMS; OSTEOARTHRITIS; EPIDEMIOLOGY; INFLAMMATION; METAANALYSIS; MANAGEMENT; RECEPTORS; TRANSPORT;

D O I：

10.1111/j.1749-6632.2009.05343.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Opioids are the most potent analgesics available and are well established for the treatment of severe acute, surgical, and cancer pain. However, their use to ameliorate chronic noncancer pain (CNCP) is still controversial because of the side effects, such as tolerance, somnolence, confusion, constipation, addiction, withdrawal, and anxiety about disapproval by regulatory bodies. Chronic rheumatic diseases along with low-back pain and arthritis are among the leading causes of CNCP. This article will focus on the role of opioids in chronic rheumatic diseases. Furthermore, the peripheral effects of opioids on pain and inflammation in rheumatic diseases will be outlined.

引用

页码：111 / 116

页数：6

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