Psychopharmacological Effects of JNK Inhibitor in Posthypoxic Encephalopathy and Mechanisms of Their Development

被引：13

作者：

Zyuz'kov, G. N. ^{[1
,2
]}

Suslov, N. I. ^{[1
]}

Povet'eva, T. N. ^{[1
]}

Nesterova, Yu. V. ^{[1
]}

Afanas'eva, O. G. ^{[1
]}

Udut, E. V. ^{[1
]}

Miroshnichenko, L. A. ^{[1
]}

Simanina, E. V. ^{[1
]}

Polyakova, T. Yu. ^{[1
]}

Stavrova, L. A. ^{[1
]}

Chaikovskii, A. V. ^{[1
]}

Kul'pin, P. V. ^{[1
]}

Udut, V. V. ^{[1
,2
]}

Dygai, A. M. ^{[1
]}

Zhdanov, V. V. ^{[1
]}

机构：

[1] Russian Acad Sci, ED Goldberg Res Inst Pharmacol & Regenerat Med, Tomsk Natl Res Med Ctr, Tomsk, Russia

[2] Natl Res Tomsk State Univ, Lab Phys Proc Modeling Biol & Med, Tomsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2017年 / 163卷 / 01期

关键词：

regenerative medicine; cerebroprotective pharmacology; JNK; neural stem cells; hypoxia; FIBROBLAST-GROWTH-FACTOR; MESENCHYMAL PROGENITOR CELLS; PRECURSOR CELLS; REALIZATION; JAK3;

D O I：

10.1007/s10517-017-3727-9

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Psychopharmacological effects of JNK inhibitor were studied using a mouse model of post-hypoxic encephalopathy. The preparation exhibited a pronounced cerebroprotective effect manifested in normalization of orientation and exploratory behavior and conditioned responses in posthypoxic mice. These effects were accompanied by marked elevation of neural stem cell content in the paraventricular region of the brain.

引用

页码：18 / 21

页数：4

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