Heterogeneity in cancer stem cells

被引：36
作者：
Wang, Anxin [1 ,2 ,3 ]
Chen, Lisha [1 ,2 ,3 ]
Li, Chunlin [1 ,2 ,3 ]
Zhu, Yimin [1 ]
机构：
[1] Chinese Acad Sci, Suzhou Inst Nanotech & Nanobion, Div Nanobiomed, Key Lab Nanobio Interface Res,Suzhou Key Lab Nano, Suzhou 215123, Peoples R China
[2] Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China
[3] Univ Chinese Acad Sci, Being 100049, Peoples R China
来源：
CANCER LETTERS | 2015年 / 357卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Cancer stem cell; Heterogeneity; Surface marker; Targeting therapy; TUMOR-INITIATING CELLS; ACUTE MYELOID-LEUKEMIA; BREAST-CANCER; EXPRESSION PROFILES; SIDE POPULATION; PROSPECTIVE IDENTIFICATION; PHENOTYPIC HETEROGENEITY; MICRORNA EXPRESSION; TARGETED THERAPY; GASTRIC-CANCER;
D O I：
10.1016/j.canlet.2014.11.040
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Accumulating evidence suggests that cancer stem cells (CSCs) are heterogeneous populations and their phenotypes are unstable. A number of intrinsic and extrinsic mechanisms contribute to CSC phenotypic variation. The existence of various CSC subpopulations which would lead to a rapid relapse after primary treatments might pose a problem for CSC targeted therapeutics. In order to develop more effective approaches to cancer therapeutics, more CSC-related surface markers or targeting molecules, as well as some novel targeting strategies should be explored. This review summarized the origin and performance of heterogeneity in CSCs and discussed their therapeutic implications. (c) 2014 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：63 / 68
页数：6
相关论文
共 103 条
  • [1] Prospective identification of tumorigenic breast cancer cells
    Al-Hajj, M
    Wicha, MS
    Benito-Hernandez, A
    Morrison, SJ
    Clarke, MF
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) : 3983 - 3988
  • [2] High ALDH Activity Identifies Chemotherapy-Resistant Ewing's Sarcoma Stem Cells That Retain Sensitivity to EWS-FLI1 Inhibition
    Awad, Ola
    Yustein, Jason T.
    Shah, Preeti
    Gul, Naheed
    Katuri, Varalakshmi
    O'Neill, Alison
    Kong, Yali
    Brown, Milton L.
    Toretsky, Jeffrey A.
    Loeb, David M.
    [J]. PLOS ONE, 2010, 5 (11):
  • [3] Differentially Expressed miRNAs in Cancer-Stem-Like Cells: Markers for Tumor Cell Aggressiveness of Pancreatic Cancer
    Bao, Bin
    Ali, Shadan
    Ahmad, Aamir
    Li, Yiwei
    Banerjee, Sanjeev
    Kong, Dejuan
    Aboukameel, Amro
    Mohammad, Ramzi
    Van Buren, Eric
    Azmi, Asfar S.
    Sarkar, Fazlul H.
    [J]. STEM CELLS AND DEVELOPMENT, 2014, 23 (16) : 1947 - 1958
  • [4] A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumours
    Beck, Benjamin
    Driessens, Gregory
    Goossens, Steven
    Youssef, Khalil Kass
    Kuchnio, Anna
    Caauwe, Amelie
    Sotiropoulou, Panagiota A.
    Loges, Sonja
    Lapouge, Gaelle
    Candi, Aurelie
    Mascre, Guilhem
    Drogat, Benjamin
    Dekoninck, Sophie
    Haigh, Jody J.
    Carmeliet, Peter
    Blanpain, Cedric
    [J]. NATURE, 2011, 478 (7369) : 399 - +
  • [5] Understanding the cancer stem cell
    Bomken, S.
    Fiser, K.
    Heidenreich, O.
    Vormoor, J.
    [J]. BRITISH JOURNAL OF CANCER, 2010, 103 (04) : 439 - 445
  • [6] Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    Bonnet, D
    Dick, JE
    [J]. NATURE MEDICINE, 1997, 3 (07) : 730 - 737
  • [7] Colon cancer stem cells - From basic to clinical application
    Botchkina, Galina
    [J]. CANCER LETTERS, 2013, 338 (01) : 127 - 140
  • [8] The causes and consequences of genetic heterogeneity in cancer evolution
    Burrell, Rebecca A.
    McGranahan, Nicholas
    Bartek, Jiri
    Swanton, Charles
    [J]. NATURE, 2013, 501 (7467) : 338 - 345
  • [9] A perivascular niche for brain tumor stem cells
    Calabrese, Christopher
    Poppleton, Helen
    Kocak, Mehmet
    Hogg, Twala L.
    Fuller, Christine
    Hamner, Blair
    Oh, Eun Young
    Gaber, M. Waleed
    Finklestein, David
    Allen, Meredith
    Frank, Adrian
    Bayazitov, Ildar T.
    Zakharenko, Stanislav S.
    Gajjar, Amar
    Davidoff, Andrew
    Gilbertson, Richard J.
    [J]. CANCER CELL, 2007, 11 (01) : 69 - 82
  • [10] The MOZ Histone Acetyltransferase in Epigenetic Signaling and Disease
    Carlson, Samuel
    Glass, Karen C.
    [J]. JOURNAL OF CELLULAR PHYSIOLOGY, 2014, 229 (11) : 1571 - 1574
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