Caffeine suppresses high-fat diet-induced body weight gain in mice depending on feeding timing

被引：8

作者：

Haraguchi, Atsushi ^{[1
]}

Yamazaki, Tomohiro ^{[1
]}

Ryan, Conn ^{[1
]}

Ito, Kaede ^{[1
]}

Sato, Shuhei ^{[1
]}

Tamura, Konomi ^{[1
]}

Sekiguchi, Masataka ^{[1
]}

Cao, Siyuan ^{[1
]}

Shibata, Shigenobu ^{[1
]}

机构：

[1] Waseda Univ, Sch Adv Sci & Engn, Lab Physiol & Pharmacol, Shinjuku Ku, Tokyo 1628480, Japan

来源：

JOURNAL OF FUNCTIONAL FOODS | 2022年 / 99卷

关键词：

Anti-obesity effect; Caffeine; Chrono-nutrition; Circadian clock system; Lipogenesis; ENERGY-EXPENDITURE; TIME; COMBINATION; OBESITY; PHASE; LIVER;

D O I：

10.1016/j.jff.2022.105307

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The time-dependent effects of caffeine intake on physiological functions remain to be investigated, although various effects of caffeine on physiological functions have been document. Therefore, the present study inves-tigated the optimal timing of caffeine intake to produce an efficient anti-obesity effect. We prepared a high-fat diet (HFD) or HFD supplemented with 0.03% caffeine (HFD-caf) and regulated twice-daily 8-hour time-restricted feeding. Male Institute of Cancer Research mice were divided into three groups: group fed HFD alone (control), group fed HFD-caf at the beginning of the active period (BF-caf), and group fed HFD-caf at the end of the active period (DN-caf). The BF-caf group (42.8 +/- 1.5 g) showed lower body weight than the other groups (control, 49.7 +/- 2.1 g; DN-caf, 47.1 +/- 1.3 g), although the three groups showed similar HFD intake levels. Therefore, caffeine intake at the beginning of the active period suppressed HFD-induced body weight gain.

引用

页数：12

共 40 条

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