Bone morphogenetic protein 7: A broad-spectrum growth factor with multiple target therapeutic potency

被引：90

作者：

Boon, Mariette R. ^{[1
]}

van der Horst, Geertje ^{[2
]}

van der Pluijm, Gabri ^{[2
]}

Tamsma, Jouke T. ^{[1
]}

Smit, Johannes W. A. ^{[1
]}

Rensen, Patrick C. N. ^{[1
]}

机构：

[1] Leiden Univ, Dept Gen Internal Med Endocrinol & Metab Dis, Med Ctr, NL-2300 RC Leiden, Netherlands

[2] Leiden Univ, Dept Urol, Med Ctr, NL-2300 RC Leiden, Netherlands

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2011年 / 22卷 / 04期

关键词：

BMP7; Brown adipose tissue; Kidney fibrosis; Bone metastasis; Obesity; BROWN ADIPOSE-TISSUE; HUMAN OSTEOGENIC PROTEIN-1; HUMAN ARTICULAR CHONDROCYTES; DIABETIC-NEPHROPATHY; GENE-EXPRESSION; FACTOR-BETA; RENAL DEVELOPMENT; HUMAN PROSTATE; BREAST-CANCER; IN-VITRO;

D O I：

10.1016/j.cytogfr.2011.08.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bone morphogenetic protein 7 (BMP7) is a member of the transforming growth factor-beta (TGF-beta) superfamily of growth factors. In recent years, it has become clear that BMP7 is a very pleiotropic growth factor. As described in this review, it plays a pivotal role in the development of bone and kidney, and has only recently been demonstrated to also be crucially involved in differentiation of brown adipose tissue. Because BMP7 thus controls the development and maintenance of many physiological processes in the human body, aberrant expression of BMP7 is associated with a variety of diseases. This review gives a broad overview on the involvement of BMP7 in several pathological conditions, such as incomplete fracture healing, osteoarthritis, the development of bone metastases, renal fibrosis and obesity. Furthermore, the therapeutic potential of BMP7 in these disease states is discussed. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：221 / 229

页数：9

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