Red and NIR Light-Responsive Polymeric Nanocarriers for On-Demand Drug Delivery

被引：5

作者：

He, Xinyu ^{[1
,2
,3
]}

Yang, Xianzhu ^{[1
]}

Li, Dongdong ^{[1
]}

Cao, Ziyang ^{[1
]}

机构：

[1] South China Univ Technol, Inst Life Sci, Sch Med, Guangzhou 510006, Guangdong, Peoples R China

[2] South China Univ Technol, Natl Engn Res Ctr Tissue Restorat & Reconstruct, Guangzhou 510006, Guangdong, Peoples R China

[3] South China Univ Technol, Key Lab Biomed Engn Guangdong Prov, Guangzhou 510006, Peoples R China

来源：

CURRENT MEDICINAL CHEMISTRY | 2020年 / 27卷 / 23期

基金：

中国国家自然科学基金; 中国博士后科学基金; 国家重点研发计划;

关键词：

Polymeric nanocarriers; red light; NIR light; drug delivery; drug release; photothermal therapy; photodynamic therapy; BLOCK-COPOLYMER MICELLES; BIOLOGICAL-SYSTEMS; CANCER-TREATMENT; GENE DELIVERY; NANOPARTICLES; THERAPY; RELEASE; PEG; DOXORUBICIN; STRATEGY;

D O I：

10.2174/0929867326666190215113522

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Red and NIR light-responsive polymeric nanocarriers capable of on-demand drug delivery have gained tremendous attention for their great potential in cancer therapy. Various strategies have been applied to fabricate such nanocarriers, and they have demonstrated significant therapeutic efficacy and minimal toxicity to normal tissues. Here, we will review the current developments in various red and NIR light-responsive polymeric nanocarriers with respect to their use in on-demand drug delivery, including facilitation of drug internalization and boosting of drug release at targeted sites. We summarize their components and design strategies, and highlight the mechanisms by which the photoactivatable variations enhance drug uptake and drug release. We attempt to provide new insights into the fabrication of red and NIR light-responsive polymeric nanocarriers for on-demand drug delivery.

引用

页码：3877 / 3887

页数：11

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