Molecular Physiology of pH-Sensitive Background K2P Channels

被引：74
作者：
Lesage, Florian [1 ,2 ]
Barhanin, Jacques [2 ]
机构：
[1] CNRS, Inst Pharmacol Mol & Cellulaire, Unite Mixte Rech 6097, F-06560 Valbonne, France
[2] Univ Nice Sophia Antipolis, UFR Sci, Nice, France
来源：
PHYSIOLOGY | 2011年 / 26卷 / 06期
关键词：
DOMAIN POTASSIUM CHANNEL; POLYUNSATURATED FATTY-ACIDS; UNION-OF-PHARMACOLOGY; ARTERY SMOOTH-MUSCLE; K+ CHANNEL; 2-PORE DOMAIN; TASK CHANNELS; EXTRACELLULAR HISTIDINE; FUNCTIONAL EXPRESSION; INDUCED INHIBITION;
D O I：
10.1152/physiol.00029.2011
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Background K-2P channels are tightly regulated by different stimuli including variations of external and internal pH. pH sensitivity relies on proton-sensing residues that influence channel gating and activity. Gene inactivation in the mouse is a revealing implication of K-2P channels in many physiological functions ranging from hormone secretion to central respiratory adaptation. Surprisingly, only a few phenotypic traits of these mice have yet been directly related to the pH sensitivity of K-2P channels.
引用
收藏
页码：424 / 437
页数：14
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