Molecular Physiology of pH-Sensitive Background K2P Channels

被引：73

作者：

Lesage, Florian ^{[1
,2
]}

Barhanin, Jacques ^{[2
]}

机构：

[1] CNRS, Inst Pharmacol Mol & Cellulaire, Unite Mixte Rech 6097, F-06560 Valbonne, France

[2] Univ Nice Sophia Antipolis, UFR Sci, Nice, France

来源：

PHYSIOLOGY | 2011年 / 26卷 / 06期

关键词：

DOMAIN POTASSIUM CHANNEL; POLYUNSATURATED FATTY-ACIDS; UNION-OF-PHARMACOLOGY; ARTERY SMOOTH-MUSCLE; K+ CHANNEL; 2-PORE DOMAIN; TASK CHANNELS; EXTRACELLULAR HISTIDINE; FUNCTIONAL EXPRESSION; INDUCED INHIBITION;

D O I：

10.1152/physiol.00029.2011

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Background K-2P channels are tightly regulated by different stimuli including variations of external and internal pH. pH sensitivity relies on proton-sensing residues that influence channel gating and activity. Gene inactivation in the mouse is a revealing implication of K-2P channels in many physiological functions ranging from hormone secretion to central respiratory adaptation. Surprisingly, only a few phenotypic traits of these mice have yet been directly related to the pH sensitivity of K-2P channels.

引用

页码：424 / 437

页数：14

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