Molecular Physiology of pH-Sensitive Background K2P Channels

被引：74
作者：
Lesage, Florian [1 ,2 ]
Barhanin, Jacques [2 ]
机构：
[1] CNRS, Inst Pharmacol Mol & Cellulaire, Unite Mixte Rech 6097, F-06560 Valbonne, France
[2] Univ Nice Sophia Antipolis, UFR Sci, Nice, France
来源：
PHYSIOLOGY | 2011年 / 26卷 / 06期
关键词：
DOMAIN POTASSIUM CHANNEL; POLYUNSATURATED FATTY-ACIDS; UNION-OF-PHARMACOLOGY; ARTERY SMOOTH-MUSCLE; K+ CHANNEL; 2-PORE DOMAIN; TASK CHANNELS; EXTRACELLULAR HISTIDINE; FUNCTIONAL EXPRESSION; INDUCED INHIBITION;
D O I：
10.1152/physiol.00029.2011
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Background K-2P channels are tightly regulated by different stimuli including variations of external and internal pH. pH sensitivity relies on proton-sensing residues that influence channel gating and activity. Gene inactivation in the mouse is a revealing implication of K-2P channels in many physiological functions ranging from hormone secretion to central respiratory adaptation. Surprisingly, only a few phenotypic traits of these mice have yet been directly related to the pH sensitivity of K-2P channels.
引用
收藏
页码：424 / 437
页数：14
相关论文
共 113 条
[1]   Modifying the subunit composition of TASK channels alters the modulation of a leak conductance in cerebellar granule neurons [J].
Aller, MI ;
Veale, EL ;
Linden, AM ;
Sandu, C ;
Schwaninger, M ;
Evans, LJ ;
Korpi, ER ;
Mathie, A ;
Wisden, W ;
Brickley, SG .
JOURNAL OF NEUROSCIENCE, 2005, 25 (49) :11455-11467
[2]   TREK-1, a K+ channel involved in polymodal pain perception [J].
Alloui, Abdelkrim ;
Zimmermann, Katharina ;
Mamet, Julien ;
Duprat, Fabrice ;
Noel, Jacques ;
Chemin, Jean ;
Guy, Nicolas ;
Blondeau, Nicolas ;
Voilley, Nicolas ;
Rubat-Coudert, Catherine ;
Borsotto, Marc ;
Romey, Georges ;
Heurteaux, Catherine ;
Reeh, Peter ;
Eschalier, Alain ;
Lazdunski, Michel .
EMBO JOURNAL, 2006, 25 (11) :2368-2376
[3]  
Alper SL, 2010, J NEPHROL, V23, pS57
[4]   TASK-5, a novel member of the tandem pore K+ channel family [J].
Ashmole, I ;
Goodwin, PA ;
Stanfield, PR .
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2001, 442 (06) :828-833
[5]   Multiple modalities converge on a common gate to control K2P channel function [J].
Bagriantsev, Sviatoslav N. ;
Peyronnet, Remi ;
Clark, Kimberly A. ;
Honore, Eric ;
Minor, Daniel L., Jr. .
EMBO JOURNAL, 2011, 30 (17) :3594-3606
[6]   TREK-2, a new member of the mechanosensitive tandem-pore K+ channel family [J].
Bang, H ;
Kim, Y ;
Kim, D .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (23) :17412-17419
[7]   Maternally inherited Birk barel mental retardation dysmorphism syndrome caused by a mutation in the genomically imprinted potassium channel KCNK9 [J].
Barel, Ortal ;
Shalev, Stavit A. ;
Ofir, Rivka ;
Cohen, Asi ;
Zlotogora, Joel ;
Shorer, Zamir ;
Mazor, Galia ;
Finer, Gal ;
Khateeb, Shareef ;
Zilberberg, Noam ;
Birk, Ohad S. .
AMERICAN JOURNAL OF HUMAN GENETICS, 2008, 83 (02) :193-199
[8]   Role of TASK2 potassium channels regarding volume regulation in primary cultures of mouse proximal tubules [J].
Barriere, H ;
Belfodil, R ;
Rubera, I ;
Tauc, M ;
Lesage, F ;
Poujeol, C ;
Guy, N ;
Barhanin, J ;
Poujeol, P .
JOURNAL OF GENERAL PHYSIOLOGY, 2003, 122 (02) :177-190
[9]   TASK-1 is a highly modulated pH-sensitive 'leak' K+ channel expressed in brainstem respiratory neurons [J].
Bayliss, DA ;
Talley, EM ;
Sirois, JE ;
Lei, QB .
RESPIRATION PHYSIOLOGY, 2001, 129 (1-2) :159-174
[10]   Inverse coupling in leak and voltage-activated K+ channel gates underlies distinct roles in electrical signaling [J].
Ben-Abu, Yuval ;
Zhou, Yufeng ;
Zilberberg, Noam ;
Yifrach, Ofer .
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2009, 16 (01) :71-79
12345678910