Studies on functionalization of poly(e-caprolactone) by a cholesteryl moiety

被引：22

作者：

Zhang, L ^{[1
]}

Wang, QR ^{[1
]}

Jiang, XS ^{[1
]}

Cheng, SX ^{[1
]}

Zhuo, RX ^{[1
]}

机构：

[1] Wuhan Univ, Dept Chem, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Peoples R China

来源：

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION | 2005年 / 16卷 / 09期

基金：

中国国家自然科学基金;

关键词：

biodegradable; functionalization of polymers; polyesters; biornaterials;

D O I：

10.1163/1568562054798527

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Biodegradable polymers/oligomers based on epsilon-caprolactone (CL) were end-functionalized by a cholesteryl moiety. The functionalized polymers/oligomers, Chol-(CL)(n), were synthesized through ring-opening polymerization initiated by cholesterol with a hydroxyl group. The chemical structure of end-functionalized polymers/oligomers was confirmed by FT-IR and H-1-NMR. The molecular weight of the functionalized polymer/oligorner increases with decreasing feed ratio of the initiator cholesterol to the monomer CL. Incorporation of the cholesteryl moiety to the polymer chain results in liquid crystallinity for the resultant oligomers when their molecular chains are not very long. The enzymatic degradation of the functionalized polymers/oligomers was investigated. The microsphere drug-delivery system of a functionalized oligomer was fabricated and its drug release properties were evaluated. The cell-culture experiment indicates the incorporation of cholesteryl moiety to the polymer chain results in improved cell proliferation.

引用

页码：1095 / 1108

页数：14

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