Near-Infrared Photoacoustic Imaging Probe Responsive to Calcium

被引：59
|
作者：
Mishra, Anurag [1 ,2 ]
Jiang, Yuanyuan [1 ,2 ,5 ]
Roberts, Sheryl [1 ,2 ,4 ]
Ntziachristos, Vasilis [1 ,3 ]
Westmeyer, Gil G. [1 ,2 ,4 ]
机构：
[1] Helmholtz Zentrum Munchen, Inst Biol & Med Imaging, D-85764 Neuherberg, Germany
[2] Helmholtz Zentrum Munchen, Inst Dev Genet, D-85764 Neuherberg, Germany
[3] Tech Univ Munich, Chair Biol Imaging, D-80333 Munich, Germany
[4] Tech Univ Munich, Dept Nucl Med, D-81675 Munich, Germany
[5] Max Planck Inst Biol Cybernet, Spemannstr 41, D-72076 Tubingen, Germany
来源：
ANALYTICAL CHEMISTRY | 2016年 / 88卷 / 22期
基金：
欧洲研究理事会;
关键词：
IN-VIVO; OPTOACOUSTIC TOMOGRAPHY; MOUSE-BRAIN; RED; VISUALIZATION; MAGNESIUM; IONS; MG2+; TIME; NMR;
D O I：
10.1021/acs.analchem.6b03039
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Photoacoustic imaging (PAI) is an attractive imaging modality that can volumetrically map the distribution of photoabsorbing molecules with deeper tissue penetration than multiphoton microscopy. To enable dynamic sensing of divalent cations via PAI, we have engineered a new reversible near-infrared probe that is more sensitive to calcium as compared to other biologically relevant cations. The metallochromic compound showed a strong reduction of its peak absorbance at 765 nm upon addition of calcium ions that was translated into robust signal changes in photoacoustic images. Therefore, the heptamethine cyanine dye will be an attractive scaffold to create a series of metallochromic sensors for molecular PAI.
引用
收藏
页码：10785 / 10789
页数：5
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