A common deletion polymorphism of the gene Bcl-2 like protein 11 (BCL2L11, BIM) has been reported to cause tyrosine kinase inhibitors (TKIs) resistance in several malignant tumors. However, the conclusions were not consistent in chronic myeloid leukemia (CML) individuals. In order to obtain a reliable conclusion, we systematically searched PubMed, Embase, Web of Science, Chinese Biomedical Database, and China National Knowledge Infrastructure and performed the meta-analysis. Six published articles contain 760 East Asian patients were identified from these electronic databases. The methodological quality of one included trial was high, and the others were moderate. Meta-analysis showed that the rate of TKI resistance between the BIM deletion and wild-type group were no statistical significance (OR = 1.24, 95% CI 0.79-1.95). In conclusion, BIM deletion may not a predictor of TKI resistance in CML individuals in East Asia.
机构:
Inha Univ, Dept Hematol Oncol, Coll Med & Hosp, 7-206 Third St, Incheon, South KoreaInha Univ, Dept Hematol Oncol, Coll Med & Hosp, 7-206 Third St, Incheon, South Korea
Park, Jisun
Moon, Yeonsook
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Inha Univ, Dept Lab Med, Coll Med & Hosp, Incheon, South KoreaInha Univ, Dept Hematol Oncol, Coll Med & Hosp, 7-206 Third St, Incheon, South Korea
Moon, Yeonsook
Choi, Suk Jin
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Inha Univ, Coll Med & Hosp, Dept Pathol, Incheon, South KoreaInha Univ, Dept Hematol Oncol, Coll Med & Hosp, 7-206 Third St, Incheon, South Korea
Choi, Suk Jin
Lim, Joo Han
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Inha Univ, Dept Hematol Oncol, Coll Med & Hosp, 7-206 Third St, Incheon, South KoreaInha Univ, Dept Hematol Oncol, Coll Med & Hosp, 7-206 Third St, Incheon, South Korea
Lim, Joo Han
Lee, Moon Hee
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Inha Univ, Dept Hematol Oncol, Coll Med & Hosp, 7-206 Third St, Incheon, South KoreaInha Univ, Dept Hematol Oncol, Coll Med & Hosp, 7-206 Third St, Incheon, South Korea
Lee, Moon Hee
Cho, Jinhyun
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Inha Univ, Dept Hematol Oncol, Coll Med & Hosp, 7-206 Third St, Incheon, South KoreaInha Univ, Dept Hematol Oncol, Coll Med & Hosp, 7-206 Third St, Incheon, South Korea
机构:
Rabin Med Ctr, Inst Hematol, Davidoff Canc Ctr, Petah Tiqwa, Israel
Tel Aviv Univ, Sackler Sch Med, Tel Aviv, IsraelRabin Med Ctr, Inst Hematol, Davidoff Canc Ctr, Petah Tiqwa, Israel
Gurion, Ronit
Raanani, Pia
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Rabin Med Ctr, Inst Hematol, Davidoff Canc Ctr, Petah Tiqwa, Israel
Tel Aviv Univ, Sackler Sch Med, Tel Aviv, IsraelRabin Med Ctr, Inst Hematol, Davidoff Canc Ctr, Petah Tiqwa, Israel
Raanani, Pia
Vidal, Liat
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h-index: 0
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Rabin Med Ctr, Inst Hematol, Davidoff Canc Ctr, Petah Tiqwa, Israel
Tel Aviv Univ, Sackler Sch Med, Tel Aviv, IsraelRabin Med Ctr, Inst Hematol, Davidoff Canc Ctr, Petah Tiqwa, Israel
Vidal, Liat
Leader, Avi
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h-index: 0
机构:
Rabin Med Ctr, Inst Hematol, Davidoff Canc Ctr, Petah Tiqwa, Israel
Tel Aviv Univ, Sackler Sch Med, Tel Aviv, IsraelRabin Med Ctr, Inst Hematol, Davidoff Canc Ctr, Petah Tiqwa, Israel
Leader, Avi
Gafter-Gvili, Anat
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Rabin Med Ctr, Inst Hematol, Davidoff Canc Ctr, Petah Tiqwa, Israel
Rabin Med Ctr, Internal Med Dept A, Petah Tiqwa, Israel
Tel Aviv Univ, Sackler Sch Med, Tel Aviv, IsraelRabin Med Ctr, Inst Hematol, Davidoff Canc Ctr, Petah Tiqwa, Israel
机构:
Univ Santiago de Compostela, Ctr Singular Invest Med Mol & Enfermedades Cron Ci, Santiago De Compostela 15782, SpainUniv Fed Para, Nucleo Pesquisas Oncol, BR-66073005 Belem, PA, Brazil
Guerrero, Raquel Cruz
Carracedo, Angel
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Univ Santiago de Compostela, Ctr Singular Invest Med Mol & Enfermedades Cron Ci, Santiago De Compostela 15782, SpainUniv Fed Para, Nucleo Pesquisas Oncol, BR-66073005 Belem, PA, Brazil
机构:
Inha Univ, Dept Hematol Oncol, Coll Med & Hosp, 7-206 Third St, Incheon, South KoreaInha Univ, Dept Hematol Oncol, Coll Med & Hosp, 7-206 Third St, Incheon, South Korea
Park, Jisun
Moon, Yeonsook
论文数: 0引用数: 0
h-index: 0
机构:
Inha Univ, Dept Lab Med, Coll Med & Hosp, Incheon, South KoreaInha Univ, Dept Hematol Oncol, Coll Med & Hosp, 7-206 Third St, Incheon, South Korea
Moon, Yeonsook
Choi, Suk Jin
论文数: 0引用数: 0
h-index: 0
机构:
Inha Univ, Coll Med & Hosp, Dept Pathol, Incheon, South KoreaInha Univ, Dept Hematol Oncol, Coll Med & Hosp, 7-206 Third St, Incheon, South Korea
Choi, Suk Jin
Lim, Joo Han
论文数: 0引用数: 0
h-index: 0
机构:
Inha Univ, Dept Hematol Oncol, Coll Med & Hosp, 7-206 Third St, Incheon, South KoreaInha Univ, Dept Hematol Oncol, Coll Med & Hosp, 7-206 Third St, Incheon, South Korea
Lim, Joo Han
Lee, Moon Hee
论文数: 0引用数: 0
h-index: 0
机构:
Inha Univ, Dept Hematol Oncol, Coll Med & Hosp, 7-206 Third St, Incheon, South KoreaInha Univ, Dept Hematol Oncol, Coll Med & Hosp, 7-206 Third St, Incheon, South Korea
Lee, Moon Hee
Cho, Jinhyun
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h-index: 0
机构:
Inha Univ, Dept Hematol Oncol, Coll Med & Hosp, 7-206 Third St, Incheon, South KoreaInha Univ, Dept Hematol Oncol, Coll Med & Hosp, 7-206 Third St, Incheon, South Korea
机构:
Rabin Med Ctr, Inst Hematol, Davidoff Canc Ctr, Petah Tiqwa, Israel
Tel Aviv Univ, Sackler Sch Med, Tel Aviv, IsraelRabin Med Ctr, Inst Hematol, Davidoff Canc Ctr, Petah Tiqwa, Israel
Gurion, Ronit
Raanani, Pia
论文数: 0引用数: 0
h-index: 0
机构:
Rabin Med Ctr, Inst Hematol, Davidoff Canc Ctr, Petah Tiqwa, Israel
Tel Aviv Univ, Sackler Sch Med, Tel Aviv, IsraelRabin Med Ctr, Inst Hematol, Davidoff Canc Ctr, Petah Tiqwa, Israel
Raanani, Pia
Vidal, Liat
论文数: 0引用数: 0
h-index: 0
机构:
Rabin Med Ctr, Inst Hematol, Davidoff Canc Ctr, Petah Tiqwa, Israel
Tel Aviv Univ, Sackler Sch Med, Tel Aviv, IsraelRabin Med Ctr, Inst Hematol, Davidoff Canc Ctr, Petah Tiqwa, Israel
Vidal, Liat
Leader, Avi
论文数: 0引用数: 0
h-index: 0
机构:
Rabin Med Ctr, Inst Hematol, Davidoff Canc Ctr, Petah Tiqwa, Israel
Tel Aviv Univ, Sackler Sch Med, Tel Aviv, IsraelRabin Med Ctr, Inst Hematol, Davidoff Canc Ctr, Petah Tiqwa, Israel
Leader, Avi
Gafter-Gvili, Anat
论文数: 0引用数: 0
h-index: 0
机构:
Rabin Med Ctr, Inst Hematol, Davidoff Canc Ctr, Petah Tiqwa, Israel
Rabin Med Ctr, Internal Med Dept A, Petah Tiqwa, Israel
Tel Aviv Univ, Sackler Sch Med, Tel Aviv, IsraelRabin Med Ctr, Inst Hematol, Davidoff Canc Ctr, Petah Tiqwa, Israel
机构:
Univ Santiago de Compostela, Ctr Singular Invest Med Mol & Enfermedades Cron Ci, Santiago De Compostela 15782, SpainUniv Fed Para, Nucleo Pesquisas Oncol, BR-66073005 Belem, PA, Brazil
Guerrero, Raquel Cruz
Carracedo, Angel
论文数: 0引用数: 0
h-index: 0
机构:
Univ Santiago de Compostela, Ctr Singular Invest Med Mol & Enfermedades Cron Ci, Santiago De Compostela 15782, SpainUniv Fed Para, Nucleo Pesquisas Oncol, BR-66073005 Belem, PA, Brazil