Eph receptors at synapses: Implications in neurodegenerative diseases

被引：57

作者：

Chen, Yu

Fu, Amy K. Y.

Ip, Nancy Y. ^{[1
]}

机构：

[1] Hong Kong Univ Sci & Technol, Div Life Sci, State Key Lab Mol Neurosci, Kowloon, Hong Kong, Peoples R China

来源：

CELLULAR SIGNALLING | 2012年 / 24卷 / 03期

关键词：

Receptor tyrosine kinase; Ephrin; Alzheimer's disease; Dendritic spine; Glutamate receptor; METABOTROPIC GLUTAMATE RECEPTORS; DENDRITIC SPINE MORPHOGENESIS; LONG-TERM POTENTIATION; FOCAL ADHESION KINASE; D-SERINE; SYNAPTIC PLASTICITY; ALZHEIMERS-DISEASE; MOLECULAR-BASIS; NERVOUS-SYSTEM; CALCIUM INFLUX;

D O I：

10.1016/j.cellsig.2011.11.016

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Precise regulation of synapse formation, maintenance and plasticity is crucial for normal cognitive function, and synaptic failure has been suggested as one of the hallmarks of neurodegenerative diseases. In this review, we describe the recent progress in our understanding of how the receptor tyrosine kinase Ephs and their ligands ephrins regulate dendritic spine morphogenesis, synapse formation and maturation, as well as synaptic plasticity. In particular, we discuss the emerging evidence implicating that deregulation of Eph/ephrin signaling contributes to the aberrant synaptic functions associated with cognitive impairment in Alzheimer's disease. Understanding how Eph/ephrin regulates synaptic function may therefore provide new insights into the development of therapeutic agents against neurodegenerative diseases. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：606 / 611

页数：6

共 86 条

[61] Notch in the Vertebrate Nervous System: An Old Dog with New Tricks [J].