Eph receptors at synapses: Implications in neurodegenerative diseases

被引：57
作者：
Chen, Yu
Fu, Amy K. Y.
Ip, Nancy Y. [1 ]
机构：
[1] Hong Kong Univ Sci & Technol, Div Life Sci, State Key Lab Mol Neurosci, Kowloon, Hong Kong, Peoples R China
来源：
CELLULAR SIGNALLING | 2012年 / 24卷 / 03期
关键词：
Receptor tyrosine kinase; Ephrin; Alzheimer's disease; Dendritic spine; Glutamate receptor; METABOTROPIC GLUTAMATE RECEPTORS; DENDRITIC SPINE MORPHOGENESIS; LONG-TERM POTENTIATION; FOCAL ADHESION KINASE; D-SERINE; SYNAPTIC PLASTICITY; ALZHEIMERS-DISEASE; MOLECULAR-BASIS; NERVOUS-SYSTEM; CALCIUM INFLUX;
D O I：
10.1016/j.cellsig.2011.11.016
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Precise regulation of synapse formation, maintenance and plasticity is crucial for normal cognitive function, and synaptic failure has been suggested as one of the hallmarks of neurodegenerative diseases. In this review, we describe the recent progress in our understanding of how the receptor tyrosine kinase Ephs and their ligands ephrins regulate dendritic spine morphogenesis, synapse formation and maturation, as well as synaptic plasticity. In particular, we discuss the emerging evidence implicating that deregulation of Eph/ephrin signaling contributes to the aberrant synaptic functions associated with cognitive impairment in Alzheimer's disease. Understanding how Eph/ephrin regulates synaptic function may therefore provide new insights into the development of therapeutic agents against neurodegenerative diseases. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码：606 / 611
页数：6
相关论文
共 86 条
[1]   Ephrin-A5 and EphA5 Interaction Induces Synaptogenesis during Early Hippocampal Development [J].
Akaneya, Yukio ;
Sohya, Kazuhiro ;
Kitamura, Akihiko ;
Kimura, Fumitaka ;
Washburn, Chris ;
Zhou, Renping ;
Ninan, Ipe ;
Tsumoto, Tadaharu ;
Ziff, Edward B. .
PLOS ONE, 2010, 5 (08)
[2]   Ephrin-B3 regulates glutamate receptor signaling at hippocampal synapses [J].
Antion, Marcia D. ;
Christie, Louisa A. ;
Bond, Allison M. ;
Dalva, Matthew B. ;
Contractor, Anis .
MOLECULAR AND CELLULAR NEUROSCIENCE, 2010, 45 (04) :378-388
[3]   B-ephrin reverse signaling is required for NMDA-independent long-term potentiation of mossy fibers in the hippocampus [J].
Armstrong, JN ;
Saganich, MJ ;
Xu, NJ ;
Henkemeyer, M ;
Heinemann, SF ;
Contractor, A .
JOURNAL OF NEUROSCIENCE, 2006, 26 (13) :3474-3481
[4]   Dendritic pathology in Alzheimer's disease [J].
Baloyannis, S. J. .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 2009, 283 (1-2) :153-157
[5]   The EphA4 receptor regulates dendritic spine remodeling by affecting β1-integrin signaling pathways [J].
Bourgin, Caroline ;
Murai, Keith K. ;
Richter, Melanie ;
Pasquale, Elena B. .
JOURNAL OF CELL BIOLOGY, 2007, 178 (07) :1295-1307
[6]   EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains [J].
Brückner, K ;
Labrador, JP ;
Scheiffele, P ;
Herb, A ;
Seeburg, PH ;
Klein, R .
NEURON, 1999, 22 (03) :511-524
[7]   Interactions between ephrin-B and metabotropic glutamate 1 receptors in brain tissue and cultured neurons [J].
Calò, L ;
Bruno, V ;
Spinsanti, P ;
Molinari, G ;
Korkhov, V ;
Esposito, Z ;
Patanè, M ;
Melchiorri, D ;
Freissmuth, M ;
Nicoletti, F .
JOURNAL OF NEUROSCIENCE, 2005, 25 (09) :2245-2254
[8]   Glial ephrin-A3 regulates hippocampal dendritic spine morphology and glutamate transport [J].
Carmona, Maria A. ;
Murai, Keith K. ;
Wang, Lei ;
Roberts, Amanda J. ;
Pasquale, Elena B. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (30) :12524-12529
[9]   GLUTAMATE TRANSPORTERS IN GLIAL PLASMA-MEMBRANES - HIGHLY DIFFERENTIATED LOCALIZATIONS REVEALED BY QUANTITATIVE ULTRASTRUCTURAL IMMUNOCYTOCHEMISTRY [J].
CHAUDHRY, FA ;
LEHRE, KP ;
CAMPAGNE, MV ;
OTTERSEN, OP ;
DANBOLT, NC ;
STORMMATHISEN, J .
NEURON, 1995, 15 (03) :711-720
[10]   Bidirectional signaling of ErbB and Eph receptors at synapses [J].
Chen, Yu ;
Fu, Amy K. Y. ;
Ip, Nancy Y. .
NEURON GLIA BIOLOGY, 2008, 4 :211-221
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