Chimpanzee adenoviral vectors as vaccines for outbreak pathogens

被引：65

作者：

Ewer, Katie ^{[1
]}

Sebastian, Sarah ^{[1
]}

Spencer, Alexandra J. ^{[1
]}

Gilbert, Sarah ^{[1
]}

Hill, Adrian V. S. ^{[1
]}

Lambe, Teresa ^{[1
]}

机构：

[1] Univ Oxford, Jenner Inst, Old Rd Campus Res Bldg,Roosevelt Dr, Oxford OX3 7DQ, England

来源：

HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2017年 / 13卷 / 12期

基金：

英国惠康基金;

关键词：

Vaccines; viral vectors; MERS Co-V; Lassa fever; Nipah; LASSA VIRUS-INFECTION; EBOLA-VIRUS; T-CELL; MOUSE MODEL; GUINEA-PIGS; RANDOMIZED-TRIAL; CANDIDATE VACCINE; IMMUNE-RESPONSE; ANIMAL-MODELS; HENDRA VIRUS;

D O I：

10.1080/21645515.2017.1383575

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The 2014-15 Ebola outbreak in West Africa highlighted the potential for large disease outbreaks caused by emerging pathogens and has generated considerable focus on preparedness for future epidemics. Here we discuss drivers, strategies and practical considerations for developing vaccines against outbreak pathogens. Chimpanzee adenoviral (ChAd) vectors have been developed as vaccine candidates for multiple infectious diseases and prostate cancer. ChAd vectors are safe and induce antigen-specific cellular and humoral immunity in all age groups, as well as circumventing the problem of pre-existing immunity encountered with human Ad vectors. For these reasons, such viral vectors provide an attractive platform for stockpiling vaccines for emergency deployment in response to a threatened outbreak of an emerging pathogen. Work is already underway to develop vaccines against a number of other outbreak pathogens and we will also review progress on these approaches here, particularly for Lassa fever, Nipah and MERS.

引用

页码：3020 / 3032

页数：13

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