Long-term effect of intra-striatal glial cell line-derived neurotrophic factor-releasing microspheres in a partial rat model of Parkinson's disease

被引：31

作者：

Jollivet, C

Aubert-Pouessel, A

Clavreul, A

Venier-Julienne, MC

Montero-Menei, CN

Benoit, JP

Menei, P ^{[1
]}

机构：

[1] CHU Angers, Dept Neurochirurgie, F-49033 Angers 01, France

[2] INSERM, ERIT M 0104, F-49100 Angers, France

来源：

NEUROSCIENCE LETTERS | 2004年 / 356卷 / 03期

关键词：

drug delivery; microspheres; glial cell line-derived neurotrophic factor; Parkinson's disease; rat;

D O I：

10.1016/j.neulet.2003.11.051

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Glial cell line-derived neurotrophic factor (GDNF) offers the possibility to stimulate axonal regeneration of mesencephalic dopaminergic neurons, which are affected in Parkinson's disease. Nevertheless, a safe and efficient GDNF delivery system that may be used in clinical trials is still lacking. In a previous study, we showed that GDNF-releasing microspheres can deliver the neurotrophic factor for 2 months, allowing in a partial rat model of Parkinson's disease a sprouting of the preserved dopaminergic fibers and functional improvement 8 weeks after the treatment. The present study confirms these previous observations and shows that the amphetamine-induced rotation score is still decreased 24 weeks after the end of GDNF delivery. Nevertheless, the improvement was not statistically significant at the latest time point due to the spontaneous reinnervation observed in the model used. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：207 / 210

页数：4

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