Monoclonal gammopathy of undetermined significance: A primary care guide

被引：8

作者：

Khouri, Jack ^{[1
]}

Samaras, Christy ^{[1
,2
]}

Valent, Jason ^{[1
,2
]}

Garcia, Alex Mejia ^{[1
]}

Faiman, Beth ^{[3
]}

Mathur, Saveta ^{[1
]}

Hamilton, Kim ^{[1
]}

Nakashima, Megan ^{[2
,4
]}

Kalaycio, Matt ^{[2
,5
,6
,7
]}

机构：

[1] Cleveland Clin, Dept Hematol & Med Oncol, Taussig Canc Inst, CA-60,10201 Carnegie Ave, Cleveland, OH 44195 USA

[2] Case Western Reserve Univ, Cleveland Clin, Lerner Coll Med, Cleveland, OH 44106 USA

[3] Cleveland Clin, Taussig Canc Inst, Dept Hematol Oncol & Blood Disorders, Cleveland, OH 44106 USA

[4] Cleveland Clin, Dept Clin Pathol, Cleveland, OH 44106 USA

[5] Cleveland Clin, Dept Hematol & Med Oncol, Bone Marrow Transplant Program, Cleveland, OH 44106 USA

[6] Cleveland Clin, Transplantat Ctr, Taussig Canc Inst, Cleveland, OH 44106 USA

[7] Cleveland Clin, Dept Canc Biol, Taussig Canc Inst, Cleveland, OH 44106 USA

来源：

CLEVELAND CLINIC JOURNAL OF MEDICINE | 2019年 / 86卷 / 01期

关键词：

MULTIPLE-MYELOMA; RISK-FACTORS; MANAGEMENT; DIAGNOSIS; PROGRESSION; SERUM; MGUS;

D O I：

10.3949/ccjm.86a.17133

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Monoclonal gammopathy of undetermined significance (MGUS) is commonly diagnosed in outpatients being worked up for an array of clinical concerns. It carries a risk of progression to myeloma and other lymphoproliferative disorders that, albeit low (1% per year), warrants regular follow-up. Patients with MGUS can be risk-stratified on the basis of the amount and type of their monoclonal protein as well as whether they have an abnormal light-chain ratio. Here, we provide a guide to the diagnosis, workup, and management of MGUS.

引用

页码：39 / 46

页数：8

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