Compensatory ingestion upon dietary restriction in Drosophila melanogaster

被引：118

作者：

Carvalho, GB ^{[1
]}

Kapahi, P ^{[1
]}

Benzer, S ^{[1
]}

机构：

[1] Buck Inst Age Res, Novato, CA 94945 USA

来源：

NATURE METHODS | 2005年 / 2卷 / 11期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/NMETH798

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Dietary restriction extends the lifespan of numerous, evolutionary diverse species(1). In D. melonogaster, a prominent model for research on the interaction between nutrition and longevity, dietary restriction is typically based on medium dilution, with possible compensatory ingestion commonty being neglected. Possible problems with this approach are revealed by using a method for direct monitoring of D. melonogaster feeding behavior. This demonstrates that dietary restriction elicits robust compensatory changes in food consumption. As a result, the effect of medium dilution is overestimated and, in certain cases, even fully compensated for. Our results strongly indicate that feeding behavior and nutritional composition act concertedly to determine fly lifespan. Feeding behavior thus emerges as a central element in D. melanogaster aging.

引用

页码：813 / 815

页数：3

共 20 条

[1] Regulation of lifespan by sensory perception in Caenorhabditis elegans [J].