Engineered cells along with smart scaffolds: critical factors for improving tissue engineering approaches

被引：4

作者：

Abpeikar, Zahra ^{[1
]}

Alizadeh, Ali Akbar ^{[1
]}

Ahmadyousefi, Yaghoub ^{[2
]}

Najafi, Ali Akbar ^{[3
]}

Safaei, Mohsen ^{[4
]}

机构：

[1] Shiraz Univ Med Sci, Sch Adv Med Sci & Technol, Dept Tissue Engn & Appl Cell Sci, Shiraz 7133654361, Iran

[2] Hamadan Univ Med Sci, Res Ctr Mol Med, Sch Med, Hamadan 6517838687, Hamadan, Iran

[3] Hormozgan Univ Med Sci, Fac Med, Student Res Comm, Bandar Abbas 7919693116, Iran

[4] Shahrekord Univ Med Sci, Sch Adv Technol, Dept Med Biotechnol, Shahrekord 8815713471, Iran

来源：

REGENERATIVE MEDICINE | 2022年 / 17卷 / 11期

关键词：

CRISPR; engineered cells; gene therapy; molecular dynamics; MSC; smart scaffold; synthetic biology; tissue engineering; MESENCHYMAL STEM-CELLS; MOLECULAR-DYNAMICS SIMULATIONS; NONVIRAL GENE DELIVERY; HUMAN BONE-MARROW; PROTEIN ADSORPTION; GROWTH-FACTOR; COMPUTATIONAL DESIGN; INDUCIBLE RELEASE; SYNTHETIC BIOLOGY; STROMAL CELLS;

D O I：

10.2217/rme-2022-0059

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

In this review, gene delivery and its applications are discussed in tissue engineering (TE); also, new techniques such as the CRISPR-Cas9 system, synthetics biology and molecular dynamics simulation to improve the efficiency of the scaffolds have been studied. CRISPR-Cas9 is expected to make significant advances in TE in the future. The fundamentals of synthetic biology have developed powerful and flexible methods for programming cells via artificial genetic circuits. The combination of regenerative medicine and artificial biology allows the engineering of cells and organisms for use in TE, biomaterials, bioprocessing and scaffold development. The dynamics of protein adsorption at the scaffold surface at the atomic level can provide valuable guidelines for the future design of TE scaffolds /implants. [GRAPHICS] .

引用

页码：855 / 876

页数：22

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