Self-Assembled Antimicrobial and Biocompatible Copolymer Films on Titanium

被引：36

作者：

Pfaffenroth, Cornelia ^{[1
]}

Winkel, Andreas ^{[2
]}

Dempwolf, Wibke ^{[1
]}

Gamble, Lara J. ^{[3
,4
]}

Castner, David G. ^{[3
,4
]}

Stiesch, Meike ^{[2
]}

Menzel, Henning ^{[1
]}

机构：

[1] Braunschweig Univ Technol, Inst Tech Chem, D-38104 Braunschweig, Germany

[2] Hannover Med Sch, Dept Prothodont, D-30625 Hannover, Germany

[3] Univ Washington, Dept Bioengn, Natl ESCA & Surface Anal Ctr Biomed Problems, Seattle, WA 98195 USA

[4] Univ Washington, Dept Chem Engn, Natl ESCA & Surface Anal Ctr Biomed Problems, Seattle, WA 98195 USA

来源：

MACROMOLECULAR BIOSCIENCE | 2011年 / 11卷 / 11期

关键词：

antimicrobial polymer coatings; biocompatibility; cell adhesion; copolymerization; medical implants; POLYMER-FILMS; PHOSPHONIC ACID; SURFACES; ATTACHMENT;

D O I：

10.1002/mabi.201100124

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Copolymers of 4-vinyl-N-hexylpyridinium bromide and dimethyl(2-methacryloyloxyethyl) phosphonate self-assemble to form ultrathin layers on titanium surfaces that show antimicrobial activity, and biocompatibility. The copolymer layers are characterized by contact angle measurements, ellipsometry and XPS. Antibacterial activity is assessed by investigation of adherence of S. mutans. Biocompatibility is rated based on human gingival fibroblast adhesion and proliferation. By balancing the opposing effects of the chemical composition on biocompatibility and antimicrobial activity, copolymer coatings are fabricated that are able to inhibit the growth of S. mutans on the surface but still show attachment of gingival fibroblasts, and therefore might prevent biofilm formation on implants.

引用

页码：1515 / 1525

页数：11

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