New therapies and insights into the changing landscape of colorectal cancer

被引：31

作者：

Kopetz, Scott ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

来源：

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY | 2019年 / 16卷 / 02期

关键词：

NIVOLUMAB; COLON;

D O I：

10.1038/s41575-018-0100-z

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

In 2018, advances were made in immunotherapy for colorectal cancers with microsatellite instability but, by contrast, immunotherapy studies in microsatellite-stable colorectal cancer had disappointing results. However, novel insights into the tumour microenvironment barriers that might limit therapeutic efficacy were identified, thereby offering new strategies.

引用

页码：79 / 80

页数：2

共 10 条

[1]

[Anonymous], 2017, J NATL CANC I

[2] Increasing Disparities in the Age-Related Incidences of Colon and Rectal Cancers in the United States, 1975-2010 [J].

Bailey, Christina E. ;

Hu, Chung-Yuan ;

You, Nancy ;

Bednarski, Brian K. ;

Rodriguez-Bigas, Miguel A. ;

Skibber, John M. ;

Cantor, Scott B. ;

Chang, George J. .

JAMA SURGERY, 2015, 150 (01) :17-22

[3] Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer [J].

Dienstmann, Rodrigo ;

Vermeulen, Louis ;

Guinney, Justin ;

Kopetz, Scott ;

Tejpar, Sabine ;

Tabernero, Josep .

NATURE REVIEWS CANCER, 2017, 17 (02) :79-92

[4] Determining Risk of Colorectal Cancer and Starting Age of Screening Based on Lifestyle, Environmental, and Genetic Factors [J].

Jeon, Jihyoun ;

Du, Mengmeng ;

Schoen, Robert E. ;

Hoffmeister, Michael ;

Newcomb, Polly A. ;

Berndt, Sonja I. ;

Caan, Bette ;

Campbell, Peter T. ;

Chan, Andrew T. ;

Chang-Claude, Jenny ;

Giles, Graham G. ;

Gong, Jian ;

Harrison, Tabitha A. ;

Huyghe, Jeroen R. ;

Jacobs, Eric J. ;

Li, Li ;

Lin, Yi ;

Le Marchand, Loic ;

Potter, John D. ;

Qu, Conghui ;

Bien, Stephanie A. ;

Zubair, Niha ;

Macinnis, Robert J. ;

Buchanan, Daniel D. ;

Hopper, John L. ;

Cao, Yin ;

Nishihara, Reiko ;

Rennert, Gad ;

Slattery, Martha L. ;

Thomas, Duncan C. ;

Woods, Michael O. ;

Prentice, Ross L. ;

Gruber, Stephen B. ;

Zheng, Yingye ;

Brenner, Hermann ;

Hayes, Richard B. ;

White, Emily ;

Peters, Ulrike ;

Hsu, Li .

GASTROENTEROLOGY, 2018, 154 (08) :2152-+

[5] Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β [J].

Lan, Yan ;

Zhang, Dong ;

Xu, Chunxiao ;

Hance, Kenneth W. ;

Marelli, Bo ;

Qi, Jin ;

Yu, Huakui ;

Qin, Guozhong ;

Sircar, Aroop ;

Hernandez, Vivian M. ;

Jenkins, Molly H. ;

Fontana, Rachel E. ;

Deshpande, Amit ;

Locke, George ;

Sabzevari, Helen ;

Radvanyi, Laszlo ;

Lo, Kin-Ming .

SCIENCE TRANSLATIONAL MEDICINE, 2018, 10 (424)

[6] Durable Clinical Benefit With Nivolumab Plus Ipilimumab in DNA Mismatch Repair-Deficient/Microsatellite Instability-High Metastatic Colorectal Cancer [J].

Overman, Michael J. ;

Lonardi, Sara ;

Wong, Ka Yeung Mark ;

Lenz, Heinz-Josef ;

Gelsomino, Fabio ;

Aglietta, Massimo ;

Morse, Michael A. ;

Van Cutsem, Eric ;

McDermott, Ray ;

Hill, Andrew ;

Sawyer, Michael B. ;

Hendlisz, Alain ;

Neyns, Bart ;

Svrcek, Magali ;

Moss, Rebecca A. ;

Ledeine, Jean-Marie ;

Cao, Z. Alexander ;

Kamble, Shital ;

Kopetz, Scott ;

Andre, Thierry .

JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (08) :773-+

[7] Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study [J].

Overman, Michael J. ;

McDermott, Ray ;

Leach, Joseph L. ;

Lonardi, Sara ;

Lenz, Heinz-Josef ;

Morse, Michael A. ;

Desai, Jayesh ;

Hill, Andrew ;

Axelson, Michael ;

Moss, Rebecca A. ;

Goldberg, Monica V. ;

Cao, Z. Alexander ;

Ledeine, Jean-Marie ;

Maglinte, Gregory A. ;

Kopetz, Scott ;

Andre, Thierry .

LANCET ONCOLOGY, 2017, 18 (09) :1182-1191

[8] TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis [J].

Tauriello, Daniele V. F. ;

Palomo-Ponce, Sergio ;

Stork, Diana ;

Berenguer-Llergo, Antonio ;

Badia-Ramentol, Jordi ;

Iglesias, Mar ;

Sevillano, Marta ;

Ibiza, Sales ;

Canellas, Adria ;

Hernando Momblona, Xavier ;

Byrom, Daniel ;

Matarin, Joan A. ;

Calon, Alexandre ;

Rivas, Elisa I. ;

Nebreda, Angel R. ;

Riera, Antoni ;

Stephan-Otto Attolini, Camille ;

Batlle, Eduard .

NATURE, 2018, 554 (7693) :538-+

[9] Colorectal Cancer Screening for Average-Risk Adults: 2018 Guideline Update From the American Cancer Society [J].

Wolf, Andrew M. D. ;

Fontham, Elizabeth T. H. ;

Church, Timothy R. ;

Flowers, Christopher R. ;

Guerra, Carmen E. ;

LaMonte, Samuel J. ;

Etzioni, Ruth ;

McKenna, Matthew T. ;

Oeffinger, Kevin C. ;

Shih, Ya-Chen Tina ;

Walter, Louise C. ;

Andrews, Kimberly S. ;

Brawley, Otis W. ;

Brooks, Durado ;

Fedewa, Stacey A. ;

Manassaram-Baptiste, Deana ;

Siegel, Rebecca L. ;

Wender, Richard C. ;

Smith, Robert A. .

CA-A CANCER JOURNAL FOR CLINICIANS, 2018, 68 (04) :250-281

[10] Tumor Mutational Burden and Response Rate to PD-1 Inhibition [J].

Yarchoan, Mark ;

Hopkins, Alexander ;

Jaffee, Elizabeth M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2017, 377 (25) :2500-2501

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