Reduction of cardiac hypertrophy in TGR(mREN2)27 by angiotensin II receptor blockade

被引：0
|
作者：
Bohm, M
Lippoldt, A
Wienen, W
Ganten, D
Bader, M
机构：
[1] MAX DELBRUCK CTR MOL MED, D-13125 BERLIN, GERMANY
[2] DR KARL THOMAE GMBH, PHARMA RES A, D-7950 BIBERACH, GERMANY
来源：
MOLECULAR AND CELLULAR BIOCHEMISTRY | 1996年 / 164卷
关键词：
heart hypertrophy; transgenic rats; hypertension; angiotensin II;
D O I：
暂无
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
TGR(mREN2)27 is a transgenic rat harboring the murine Ren-2 gene and exhibit fulminant hypertension and marked heart hypertrophy. In order to study the role of angiotensin II in the increase of cardiac mass, these animals were treated with antihypertensive and non-antihypertensive doses of the angiotensin II receptor AT(1) antagonist Telmisartan for 9 weeks. All doses led to significant reductions of heart hypertrophy detected by the evaluation of the diameter of cardiac muscle bundles, We conclude from this study that cardiac hypertrophy in TGR(mREN2)27 is characterized by an increased volume of cardiomyocytes and an unchanged amount of fibrous tissue and that angiotensin II plays an important role in the mechanisms leading to this phenotype.
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收藏
页码：217 / 221
页数：5
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