Acute Myeloid Leukemia Immunophenotyping by Flow Cytometric Analysis

被引：35
作者：
Chen, Xueyan [1 ]
Cherian, Sindhu [1 ]
机构：
[1] Univ Washington, Dept Lab Med, 1959 NE Pacific St, Seattle, WA 98195 USA
来源：
CLINICS IN LABORATORY MEDICINE | 2017年 / 37卷 / 04期
关键词：
Flow cytometry; Acute myeloid leukemia; Mixed phenotype acute leukemia; Minimal residual disease; ACUTE PROMYELOCYTIC LEUKEMIA; MINIMAL RESIDUAL DISEASE; ACUTE MYELOGENOUS LEUKEMIA; TRANS-RETINOIC ACID; HEALTH-ORGANIZATION CLASSIFICATION; ACUTE LYMPHOBLASTIC-LEUKEMIA; BIPHENOTYPIC ACUTE-LEUKEMIA; HUMAN-BONE-MARROW; CD56; EXPRESSION; ANTIGEN-EXPRESSION;
D O I：
10.1016/j.cll.2017.07.003
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Flow cytometry plays an indispensible role in the diagnosis and subclassification of acute myeloid leukemia (AML). Using a multiparametric approach, flow cytometry immunophenotyping has the advantage of efficiency with high sensitivity. This article reviews the general gating strategy, antibody panels for routine analysis, and additional markers for lineage assignment in the subclassification of AML. Also discussed are diagnostic immunophenotypic features of hard-to-classify entities considered within the differential diagnosis of AML. Finally, briefly presented are the principles underlying the use of flow cytometry for minimal residual disease detection.
引用
收藏
页码：753 / +
页数：18
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