Gentamicin-Loaded Poly(acrylic acid)-Grafted Cotton Fibers, Part 1: Synthesis, Characterization, and Preliminary Drug Release Study

被引：7

作者：

Bajpai, Sunil K. ^{[1
]}

Das, Pratima ^{[2
]}

机构：

[1] Govt Model Sci Coll Autonomous, Dept Chem, Polymer Res Lab, Jabalpur 482001, MP, India

[2] Smt CHM Coll, Dept Chem, Ulhasnagar 421001, Maharashtra, India

来源：

JOURNAL OF APPLIED POLYMER SCIENCE | 2011年 / 122卷 / 01期

关键词：

grafting; cotton; polymerization; drug release; IN-VITRO; CELLULOSE; ACRYLONITRILE; MODEL;

D O I：

10.1002/app.34065

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

This study describes preparation of poly (acrylic acid)-grafted cotton fibers and release of antibiotic drug gentamicin sulfate from them under physiological conditions. Poly(acrylic acid) has been grafted onto cellulose backbone of cotton fibers via Ce(IV)-initiated polymerization in aqueous medium. The conditions obtained for optimum grafting were as follows: initiation time 30 min; initiation temperature 37 degrees C; monomer concentration 27.8 mM; grafting temperature 30 degrees C; nitric acid (catalyst) concentration 0.1M. The grafted fibers were characterized by FTIR, TGA, and SEM analysis. The antibiotic drug gentamicin sulfate (GS) was loaded into the grafted fibers by equilibration method and release was studied under physiological conditions. The kinetic release data was interpreted by first-order kinetic model. Finally, drug-loaded fibers showed fair antibacterial action against Escherichia coli. (c) 2011 Wiley Periodicals, Inc. J Appl Polym Sci 122: 366-374, 2011

引用

页码：366 / 374

页数：9

共 31 条

[1] Thermal decomposition behaviour of ethyl cellulose grafted copolymers in homogeneous media [J].

Aggour, YA .

JOURNAL OF MATERIALS SCIENCE, 2000, 35 (07) :1623-1627

[2] Modulation of dynamic release of vitamin B2 from a model pH-sensitive terpolymeric hydrogel system [J].

Bajpai, SK ;

Dubey, S .

POLYMER INTERNATIONAL, 2004, 53 (12) :2178-2187

[3]

BAJPAI SK, 2010, NAT FIBERS, V7, P34

[4] The composition of serous fluid after axillary dissection [J].

Bonnema, J ;

Ligtenstein, DA ;

Wiggers, T ;

van Geel, AN .

EUROPEAN JOURNAL OF SURGERY, 1999, 165 (01) :9-13

[5]

Borbely E., 2005, ACTA POLYTECH HUNG, V2, P67

[6] In vitro gentamicin sustained and controlled release from chitosan cross-linked films [J].

Campos, Maria G. N. ;

Rawls, Henry R. ;

Innocentini-Mei, Lucia H. ;

Satsangi, Neera .

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2009, 20 (02) :537-542

[7] Antibiotic-eluting bioresorbable composite fibers for wound healing applications: Microstructure, drug delivery and mechanical properties [J].

Elsner, Jonathan J. ;

Zilberman, Meital .

ACTA BIOMATERIALIA, 2009, 5 (08) :2872-2883

[8]

FEN L, 2010, J APPL POLYM SCI, V116, P2151

[9] DIFFUSION IN GLASSY POLYMERS .2. [J].

FRISCH, HL ;

WANG, TT ;

KWEI, TK .

JOURNAL OF POLYMER SCIENCE PART A-2-POLYMER PHYSICS, 1969, 7 (5PA2) :879-&

[10]

Grace M, 2009, J ENG FIBER FABR, V4, P24

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