How proteins move lipids and lipids move proteins

被引：456
|
作者：
Sprong, H
van der Sluijs, P
van Meer, G
机构：
[1] Univ Amsterdam, Acad Med Ctr, Dept Cell Biol & Histol, NL-1100 DE Amsterdam, Netherlands
[2] Univ Utrecht, Med Ctr, Dept Cell Biol, Inst Biomembranes, NL-3584 CX Utrecht, Netherlands
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2001年 / 2卷 / 07期
关键词：
D O I：
10.1038/35080071
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Cells determine the bilayer characteristics of different membranes by tightly controlling their lipid composition. Local changes in the physical properties of bilayers, in turn, allow membrane deformation, and facilitate vesicle budding and fusion. Moreover, specific lipids at specific locations recruit cytosolic proteins involved in structural functions or signal transduction. We describe here how the distribution of lipids is directed by proteins, and, conversely, how lipids influence the distribution and function of proteins.
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页码：504 / 513
页数：10
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