SARS-CoV-2 vaccine protection and deaths among US veterans during 2021

被引：179

作者：

Cohn, Barbara A. ^{[1
]}

Cirillo, Piera M. ^{[1
,2
]}

Murphy, Caitlin C. ^{[3
]}

Krigbaum, Nickilou Y. ^{[1
,2
]}

Wallace, Arthur W. ^{[2
,4
]}

机构：

[1] Publ Hlth Inst, Oakland, CA USA

[2] San Francisco VA Med Ctr, San Francisco, CA 94121 USA

[3] Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Houston, TX 77030 USA

[4] Univ Calif San Francisco, Dept Anesthesiol & Perioperat Care, San Francisco, CA 94143 USA

来源：

SCIENCE | 2022年 / 375卷 / 6578期

关键词：

COVID-19; VACCINES; FRONTLINE WORKERS; HOSPITALIZATIONS; INFECTION; LOCATIONS; BNT162B2;

D O I：

10.1126/science.abm0620

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We report severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine effectiveness against infection (VE-I) and death (VE-D) by vaccine type in 780,225 veterans in the Veterans Health Administration, covering 2.7% of the US population. From February to October 2021, VE-I declined for all vaccine types, and the decline was greatest for the Janssen vaccine, resulting in a VE-I of 13.1%. Although breakthrough infection increased risk of death, vaccination remained protective against death in persons who became infected during the Delta variant surge. From July to October 2021, VE-D for age <65 years was 73.0% for Janssen, 81.5% for Moderna, and 84.3% for Pfizer-BioNTech; VE-D for age >= 65 years was 52.2% for Janssen, 75.5% for Moderna, and 70.1% for Pfizer-BioNTech. Findings support continued efforts to increase vaccination, booster campaigns, and multiple additional layers of protection against infection.

引用

页码：331 / +

页数：25

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