Differential and strain-specific triggering of bovine alveolar macrophage effector functions by mycoplasmas

被引:52
作者
Jungi, TW
Krampe, M
Sileghem, M
Griot, C
Nicolet, J
机构
[1] UNIV BERN,INST VET BACTERIOL,CH-3012 BERN,SWITZERLAND
[2] INT LIVESTOCK RES INST,NAIROBI,KENYA
[3] INST VIROL & IMMUNOPROPHYLAXIS,MITTELHAUSERN,SWITZERLAND
关键词
Mycoplasma mycoides cluster; bovine alveolar macrophages; tumour necrosis factor; procoagulant; nitric oxide;
D O I
10.1006/mpat.1996.0078
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Mycoplasma strains being considered as pathogenic or non-pathogenic for cattle were tested on their capacity to activate bovine alveolar macrophages in vitro. Of particular interest was the behaviour of Mycoplasma mycoides ssp. mycoides small colony type (M.m.m. SC), the causative agent of contagious bovine pleuropneumonia (CBPP). Increases in procoagulant activity (PCA), tumor necrosis factor-alpha (TNF-alpha) and nitrogen monoxide (NO) generation were tested. To minimize an influence of macrophage activation by mycoplasma growth media, mycoplasmas were cultured on embryonic calf nose epithelial cells. The three macrophage functions tested were not correlated, but were differentially induced in strain-specific manner. Four out of seven strains induced PCA, regardless of pathogenicity, and all strains promoted moderate NO generation at high concentrations. All tested M.m.m. SC strains (Afade, L2 and PG1), and the pathogenic M. bovis, induced TN F-alpha production at low concentrations (10(6) colony forming units per ml). M. sp. serogroup 7 and the non-pathogenic n/l. bovirhinis and Acholeplasma laidlawii did not induce TNF-alpha: up to 10(8) cfu/ml. Thus, strain-specific differences are reflected in differential macrophage activation patterns. The findings are consistent with an important role for TNF-alpha in pathogenesis of CBPP. (C) 1996 Academic Press Limited
引用
收藏
页码:487 / 498
页数:12
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