Serum antimullerian hormone levels are independently related to miscarriage rates after in vitro fertilization-embryo transfer

Objective: To investigate whether serum antimullerian hormone (AMH) levels are independently related to miscarriage rates after in vitro fertilization-embryo transfer (IVF-ET). Design: Cohort study. Setting: University-affiliated IVF-ET center. Patient(s): A total of 1,060 patients who attained a clinical pregnancy after IVF-ET. Interventions(s): Centralized serum AMH measurements were performed within the 12 months before IVF-ET. Binary logistic regression was used to verify whether serum AMH levels were associated with the occurrence of a miscarriage independently from confounding factors, such as age and intensity of ovarian response to controlled ovarian stimulation assessed by the number of oocytes retrieved. Main Outcome Measure(s): Miscarriage rates. Result(s): In patients displaying reduced serum AMH levels, miscarriage rates were significantly increased independently from age and the number of oocytes retrieved. Conclusion(s): The present data indicate that serum AMH levels are independently associated with the occurrence of a miscarriage after IVF-ET. (C) 2017 by American Society for Reproductive Medicine.