Facilitation of addition-elimination reactions in pyrimidines and purines using trifluoroacetic acid in trifluoroethanol

被引：27
|
作者：
Whitfield, HJ [1 ]
Griffin, RJ [1 ]
Hardcastle, IR [1 ]
Henderson, A [1 ]
Meneyrol, J [1 ]
Mesguiche, V [1 ]
Sayle, KL [1 ]
Golding, BT [1 ]
机构：
[1] Newcastle Univ, Sch Nat Sci Chem, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
来源：
CHEMICAL COMMUNICATIONS | 2003年 / 22期
关键词：
D O I：
10.1039/b308948g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
SNAr displacement reactions of 6-cyclohexylmethoxy-2-fluoropurine, 6-amino-2-butylsulfonyl-4-cyclohexylmethoxypyrimidine and 2-amino-6-chloropurine with substituted anilines (e.g. the weakly nucleophilic 4-aminobenzenesulfonamide) are dramatically accelerated in the presence of trifluoroacetic acid and occur especially efficiently in 2,2,2-trifluoroethanol solvent.
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页码：2802 / 2803
页数：2
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