A mild and efficient one-step synthesis of quinolines

被引：259
|
作者：
McNaughton, BR
Miller, BL
机构：
[1] Univ Rochester, Dept Dermatol, Dept Chem, Rochester, NY 14642 USA
[2] Univ Rochester, Ctr Future Hlth, Rochester, NY 14642 USA
来源：
ORGANIC LETTERS | 2003年 / 5卷 / 23期
关键词：
D O I：
10.1021/ol035333q
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The Friedlander synthesis of quinolines is an extensively employed protocol, yielding the desired heterocycle in a two-step reduction-condensation sequence. We have developed a mild, efficient, high-yielding single-step variant of this methodology, which employs SnCl2 and ZnCl2 to effect the reaction.
引用
收藏
页码：4257 / 4259
页数：3
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