Frailty and cognitive decline

被引：94

作者：

Fabricio, Daiene De Morais

Chagas, Marcos Hortes N.

Diniz, Breno S.

机构：

[1] Univ Fed Sao Carlos, Dept Psychol, Sao Carlos, SP, Brazil

[2] Univ Fed Sao Carlos, Dept Gerontol, Sao Carlos, SP, Brazil

[3] Ctr Addict & Mental Hlth CAMH, Adult Neurodev & Geriatr Psychiat Div, Toronto, ON, Canada

[4] Ctr Addict & Mental Hlth CAMH, Platform Peripheral Biomarkers Discovery, Toronto, ON, Canada

[5] Univ Toronto, Fac Med, Dept Psychiat, Toronto, ON, Canada

来源：

TRANSLATIONAL RESEARCH | 2020年 / 221卷

关键词：

ALZHEIMERS-DISEASE; DNA METHYLATION; INFLAMMATORY MARKERS; OXIDATIVE STRESS; OLDER-ADULTS; PHYSICAL FRAILTY; ERMELINO MATARAZZO; GLOBAL CHANGES; SAO-PAULO; IMPAIRMENT;

D O I：

10.1016/j.trsl.2020.01.002

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Frailty and cognitive impairment are among the 2 most common geriatric syndromes. Their presence poses major risks to the elderly including greater disability, reduced quality of life, and higher morbi-mortality. Recent evidence suggest that frailty can be a risk factor for incident dementia. The opposite is also true since subjects with Alzheimer's disease and other dementia also present with more severe frailty measures. The mechanisms for the association between frailty and cognitive impairment is not clear, but possibly involves abnormalities in biological processes related to aging. Here, we will review the current evidence of the association between frailty and cognitive impairment. We will also review the possible biological mechanistic links between the 2 conditions. Finally, we will address potential therapeutic targets and interventions that can mitigate both conditions.

引用

页码：58 / 64

页数：7

共 81 条

[21] Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain [J].

Coppieters, Natacha ;

Dieriks, Birger V. ;

Lill, Claire ;

Faull, Richard L. M. ;

Curtis, Maurice A. ;

Dragunow, Mike .

NEUROBIOLOGY OF AGING, 2014, 35 (06) :1334-1344

[22] Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci [J].

De Jager, Philip L. ;

Srivastava, Gyan ;

Lunnon, Katie ;

Burgess, Jeremy ;

Schalkwyk, Leonard C. ;

Yu, Lei ;

Eaton, Matthew L. ;

Keenan, Brendan T. ;

Ernst, Jason ;

McCabe, Cristin ;

Tang, Anna ;

Raj, Towfique ;

Replogle, Joseph ;

Brodeur, Wendy ;

Gabriel, Stacey ;

Chai, High S. ;

Younkin, Curtis ;

Younkin, Steven G. ;

Zou, Fanggeng ;

Szyf, Moshe ;

Epstein, Charles B. ;

Schneider, Julie A. ;

Bernstein, Bradley E. ;

Meissner, Alex ;

Ertekin-Taner, Nilufer ;

Chibnik, Lori B. ;

Kellis, Manolis ;

Mill, Jonathan ;

Bennett, David A. .

NATURE NEUROSCIENCE, 2014, 17 (09) :1156-1163

[23] Global changes in DNA methylation in Alzheimer's disease peripheral blood mononuclear cells [J].

Di Francesco, Andrea ;

Arosio, Beatrice ;

Falconi, Anastasia ;

Di Bonaventura, Maria Vittoria Micioni ;

Karimi, Mohsen ;

Mari, Daniela ;

Casati, Martina ;

Maccarrone, Mauro ;

D'Addario, Claudio .

BRAIN BEHAVIOR AND IMMUNITY, 2015, 45 :139-144

[24] Higher Serum sTNFR1 Level Predicts Conversion from Mild Cognitive Impairment to Alzheimer's Disease [J].

Diniz, Breno Satler ;

Teixeira, Antonio Lucio ;

Ojopi, Elida Benquique ;

Talib, Leda Leme ;

Mendonca, Vanessa Amaral ;

Gattaz, Wagner Farid ;

Forlenza, Orestes Vicente .

JOURNAL OF ALZHEIMERS DISEASE, 2010, 22 (04) :1305-1311

[25] Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty [J].

Ferrucci, Luigi ;

Fabbri, Elisa .

NATURE REVIEWS CARDIOLOGY, 2018, 15 (09) :505-522

[26] The APOE Gene is Differentially Methylated in Alzheimer's Disease [J].

Foraker, Jessica ;

Millard, Steven P. ;

Leong, Lesley ;

Thomson, Zachary ;

Chen, Sunny ;

Keene, C. Dirk ;

Bekris, Lynn M. ;

Yu, Chang-En .

JOURNAL OF ALZHEIMERS DISEASE, 2015, 48 (03) :745-755

[27] Increased Serum IL-1β Level in Alzheimer's Disease and Mild Cognitive Impairment [J].

Forlenza, Orestes Vicente ;

Diniz, Breno Satler ;

Talib, Leda Leme ;

Mendonca, Vanessa Amaral ;

Ojopi, Elida B. ;

Gattaz, Wagner Farid ;

Teixeira, Antonio Lucio .

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2009, 28 (06) :507-512

[28] Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans [J].

Franceschi, Claudio ;

Capri, Miriam ;

Monti, Daniela ;

Giunta, Sergio ;

Olivieri, Fabiola ;

Sevini, Federica ;

Panouraia, Maria Panagiota ;

Invidia, Laura ;

Celani, Laura ;

Scurti, Maria ;

Cevenini, Elisa ;

Castellani, Gastone C. ;

Salvioli, Stefano .

MECHANISMS OF AGEING AND DEVELOPMENT, 2007, 128 (01) :92-105

[29] Frailty in older adults: Evidence for a phenotype [J].

Fried, LP ;

Tangen, CM ;

Walston, J ;

Newman, AB ;

Hirsch, C ;

Gottdiener, J ;

Seeman, T ;

Tracy, R ;

Kop, WJ ;

Burke, G ;

McBurnie, MA .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2001, 56 (03) :M146-M156

[30] DNA methylation and the epigenetic clock in relation to physical frailty in older people: the Lothian Birth Cohort 1936 [J].

Gale, Catharine R. ;

Marioni, Riccardo E. ;

Harris, Sarah E. ;

Starr, John M. ;

Deary, Ian J. .

CLINICAL EPIGENETICS, 2018, 10

← 1 2 3 4 5 6 7 8 9 →