Frailty and cognitive decline

被引：81
作者：
Fabricio, Daiene De Morais
Chagas, Marcos Hortes N.
Diniz, Breno S.
机构：
[1] Univ Fed Sao Carlos, Dept Psychol, Sao Carlos, SP, Brazil
[2] Univ Fed Sao Carlos, Dept Gerontol, Sao Carlos, SP, Brazil
[3] Ctr Addict & Mental Hlth CAMH, Adult Neurodev & Geriatr Psychiat Div, Toronto, ON, Canada
[4] Ctr Addict & Mental Hlth CAMH, Platform Peripheral Biomarkers Discovery, Toronto, ON, Canada
[5] Univ Toronto, Fac Med, Dept Psychiat, Toronto, ON, Canada
来源：
TRANSLATIONAL RESEARCH | 2020年 / 221卷
关键词：
ALZHEIMERS-DISEASE; DNA METHYLATION; INFLAMMATORY MARKERS; OXIDATIVE STRESS; OLDER-ADULTS; PHYSICAL FRAILTY; ERMELINO MATARAZZO; GLOBAL CHANGES; SAO-PAULO; IMPAIRMENT;
D O I：
10.1016/j.trsl.2020.01.002
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Frailty and cognitive impairment are among the 2 most common geriatric syndromes. Their presence poses major risks to the elderly including greater disability, reduced quality of life, and higher morbi-mortality. Recent evidence suggest that frailty can be a risk factor for incident dementia. The opposite is also true since subjects with Alzheimer's disease and other dementia also present with more severe frailty measures. The mechanisms for the association between frailty and cognitive impairment is not clear, but possibly involves abnormalities in biological processes related to aging. Here, we will review the current evidence of the association between frailty and cognitive impairment. We will also review the possible biological mechanistic links between the 2 conditions. Finally, we will address potential therapeutic targets and interventions that can mitigate both conditions.
引用
收藏
页码：58 / 64
页数：7
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