Frailty and cognitive decline

被引：94
作者：
Fabricio, Daiene De Morais
Chagas, Marcos Hortes N.
Diniz, Breno S.
机构：
[1] Univ Fed Sao Carlos, Dept Psychol, Sao Carlos, SP, Brazil
[2] Univ Fed Sao Carlos, Dept Gerontol, Sao Carlos, SP, Brazil
[3] Ctr Addict & Mental Hlth CAMH, Adult Neurodev & Geriatr Psychiat Div, Toronto, ON, Canada
[4] Ctr Addict & Mental Hlth CAMH, Platform Peripheral Biomarkers Discovery, Toronto, ON, Canada
[5] Univ Toronto, Fac Med, Dept Psychiat, Toronto, ON, Canada
来源：
TRANSLATIONAL RESEARCH | 2020年 / 221卷
关键词：
ALZHEIMERS-DISEASE; DNA METHYLATION; INFLAMMATORY MARKERS; OXIDATIVE STRESS; OLDER-ADULTS; PHYSICAL FRAILTY; ERMELINO MATARAZZO; GLOBAL CHANGES; SAO-PAULO; IMPAIRMENT;
D O I：
10.1016/j.trsl.2020.01.002
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Frailty and cognitive impairment are among the 2 most common geriatric syndromes. Their presence poses major risks to the elderly including greater disability, reduced quality of life, and higher morbi-mortality. Recent evidence suggest that frailty can be a risk factor for incident dementia. The opposite is also true since subjects with Alzheimer's disease and other dementia also present with more severe frailty measures. The mechanisms for the association between frailty and cognitive impairment is not clear, but possibly involves abnormalities in biological processes related to aging. Here, we will review the current evidence of the association between frailty and cognitive impairment. We will also review the possible biological mechanistic links between the 2 conditions. Finally, we will address potential therapeutic targets and interventions that can mitigate both conditions.
引用
收藏
页码：58 / 64
页数：7
相关论文
共 81 条
[1]   Role of Frailty in Patients With Cardiovascular Disease [J].
Afilalo, Jonathan ;
Karunananthan, Sathya ;
Eisenberg, Mark J. ;
Alexander, Karen P. ;
Bergman, Howard .
AMERICAN JOURNAL OF CARDIOLOGY, 2009, 103 (11) :1616-1621
[2]   Is Frailty a Prodromal Stage of Vascular Dementia? Results From the Three-City Study [J].
Alberto Avila-Funes, Jose ;
Carcaillon, Laure ;
Helmer, Catherine ;
Carriere, Isabelle ;
Ritchie, Karen ;
Rouaud, Olivier ;
Tzourio, Christophe ;
Dartigues, Jean-Francois ;
Amieva, Helene .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2012, 60 (09) :1708-1712
[3]   Frailty and sarcopenia as the basis for the phenotypic manifestation of chronic diseases in older adults [J].
Angulo, Javier ;
El Assar, Mariam ;
Rodriguez-Manas, Leocadio .
MOLECULAR ASPECTS OF MEDICINE, 2016, 50 :1-32
[4]   Characterizing mild cognitive disorders in the young-old over 8 years: Prevalence, estimated incidence, stability of diagnosis, and impact on IADLs [J].
Anstey, Kaarin J. ;
Cherbuin, Nicolas ;
Eramudugolla, Ranmalee ;
Sargent-Cox, Kerry ;
Easteal, Simon ;
Kumar, Rajeev ;
Sachdev, Perminder .
ALZHEIMERS & DEMENTIA, 2013, 9 (06) :640-648
[5]   Examining three frailty conceptualizations in their ability to predict negative outcomes for home-care clients [J].
Armstrong, Joshua J. ;
Stolee, Paul ;
Hirdes, John P. ;
Poss, Jeff W. .
AGE AND AGEING, 2010, 39 (06) :755-758
[6]   Functional Decline in Cognitive Impairment - The Relationship between Physical and Cognitive Function [J].
Auyeung, Tung Wai ;
Kwok, Timothy ;
Lee, Jenny ;
Leung, Ping Chung ;
Leung, Jason ;
Woo, Jean .
NEUROEPIDEMIOLOGY, 2008, 31 (03) :167-173
[7]   Cognitive Impairment Improves the Predictive Validity of the Phenotype of Frailty for Adverse Health Outcomes: The Three-City Study [J].
Avila-Funes, Jose Alberto ;
Amieva, Helene ;
Barberger-Gateau, Pascale ;
Le Goff, Melanie ;
Raoux, Nadine ;
Ritchie, Karen ;
Carriere, Isabelle ;
Tavernier, Beatrice ;
Tzourio, Christophe ;
Gutierrez-Robledo, Luis Miguel ;
Dartigues, Jean-Francois .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2009, 57 (03) :453-461
[8]   Low-grade chronic inflammation and superoxide anion production by NADPH oxidase are the main determinants of physical frailty in older adults [J].
Baptista, Gregory ;
Dupuy, Anne-Marie ;
Jaussent, Audrey ;
Durant, Richard ;
Ventura, Emilie ;
Sauguet, Pauline ;
Picot, Marie-Christine ;
Jeandel, Claude ;
Cristol, Jean Paul .
FREE RADICAL RESEARCH, 2012, 46 (09) :1108-1114
[9]   Immune-endocrine biomarkers as predictors of frailty and mortality: a 10-year longitudinal study in community-dwelling older people [J].
Baylis, D. ;
Bartlett, D. B. ;
Syddall, H. E. ;
Ntani, G. ;
Gale, C. R. ;
Cooper, C. ;
Lord, J. M. ;
Sayer, A. A. .
AGE, 2013, 35 (03) :963-971
[10]   DNA methylation in repetitive elements and Alzheimer disease [J].
Bollati, V. ;
Galimberti, D. ;
Pergoli, L. ;
Dalla Valle, E. ;
Barretta, F. ;
Cortini, F. ;
Scarpini, E. ;
Bertazzi, P. A. ;
Baccarelli, A. .
BRAIN BEHAVIOR AND IMMUNITY, 2011, 25 (06) :1078-1083
123456789