Frailty and cognitive decline

被引：81
作者：
Fabricio, Daiene De Morais
Chagas, Marcos Hortes N.
Diniz, Breno S.
机构：
[1] Univ Fed Sao Carlos, Dept Psychol, Sao Carlos, SP, Brazil
[2] Univ Fed Sao Carlos, Dept Gerontol, Sao Carlos, SP, Brazil
[3] Ctr Addict & Mental Hlth CAMH, Adult Neurodev & Geriatr Psychiat Div, Toronto, ON, Canada
[4] Ctr Addict & Mental Hlth CAMH, Platform Peripheral Biomarkers Discovery, Toronto, ON, Canada
[5] Univ Toronto, Fac Med, Dept Psychiat, Toronto, ON, Canada
来源：
TRANSLATIONAL RESEARCH | 2020年 / 221卷
关键词：
ALZHEIMERS-DISEASE; DNA METHYLATION; INFLAMMATORY MARKERS; OXIDATIVE STRESS; OLDER-ADULTS; PHYSICAL FRAILTY; ERMELINO MATARAZZO; GLOBAL CHANGES; SAO-PAULO; IMPAIRMENT;
D O I：
10.1016/j.trsl.2020.01.002
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Frailty and cognitive impairment are among the 2 most common geriatric syndromes. Their presence poses major risks to the elderly including greater disability, reduced quality of life, and higher morbi-mortality. Recent evidence suggest that frailty can be a risk factor for incident dementia. The opposite is also true since subjects with Alzheimer's disease and other dementia also present with more severe frailty measures. The mechanisms for the association between frailty and cognitive impairment is not clear, but possibly involves abnormalities in biological processes related to aging. Here, we will review the current evidence of the association between frailty and cognitive impairment. We will also review the possible biological mechanistic links between the 2 conditions. Finally, we will address potential therapeutic targets and interventions that can mitigate both conditions.
引用
收藏
页码：58 / 64
页数：7
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共 81 条
  • [1] Role of Frailty in Patients With Cardiovascular Disease
    Afilalo, Jonathan
    Karunananthan, Sathya
    Eisenberg, Mark J.
    Alexander, Karen P.
    Bergman, Howard
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 2009, 103 (11) : 1616 - 1621
  • [2] Is Frailty a Prodromal Stage of Vascular Dementia? Results From the Three-City Study
    Alberto Avila-Funes, Jose
    Carcaillon, Laure
    Helmer, Catherine
    Carriere, Isabelle
    Ritchie, Karen
    Rouaud, Olivier
    Tzourio, Christophe
    Dartigues, Jean-Francois
    Amieva, Helene
    [J]. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2012, 60 (09) : 1708 - 1712
  • [3] Frailty and sarcopenia as the basis for the phenotypic manifestation of chronic diseases in older adults
    Angulo, Javier
    El Assar, Mariam
    Rodriguez-Manas, Leocadio
    [J]. MOLECULAR ASPECTS OF MEDICINE, 2016, 50 : 1 - 32
  • [4] Characterizing mild cognitive disorders in the young-old over 8 years: Prevalence, estimated incidence, stability of diagnosis, and impact on IADLs
    Anstey, Kaarin J.
    Cherbuin, Nicolas
    Eramudugolla, Ranmalee
    Sargent-Cox, Kerry
    Easteal, Simon
    Kumar, Rajeev
    Sachdev, Perminder
    [J]. ALZHEIMERS & DEMENTIA, 2013, 9 (06) : 640 - 648
  • [5] Examining three frailty conceptualizations in their ability to predict negative outcomes for home-care clients
    Armstrong, Joshua J.
    Stolee, Paul
    Hirdes, John P.
    Poss, Jeff W.
    [J]. AGE AND AGEING, 2010, 39 (06) : 755 - 758
  • [6] Functional Decline in Cognitive Impairment - The Relationship between Physical and Cognitive Function
    Auyeung, Tung Wai
    Kwok, Timothy
    Lee, Jenny
    Leung, Ping Chung
    Leung, Jason
    Woo, Jean
    [J]. NEUROEPIDEMIOLOGY, 2008, 31 (03) : 167 - 173
  • [7] Cognitive Impairment Improves the Predictive Validity of the Phenotype of Frailty for Adverse Health Outcomes: The Three-City Study
    Avila-Funes, Jose Alberto
    Amieva, Helene
    Barberger-Gateau, Pascale
    Le Goff, Melanie
    Raoux, Nadine
    Ritchie, Karen
    Carriere, Isabelle
    Tavernier, Beatrice
    Tzourio, Christophe
    Gutierrez-Robledo, Luis Miguel
    Dartigues, Jean-Francois
    [J]. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2009, 57 (03) : 453 - 461
  • [8] Low-grade chronic inflammation and superoxide anion production by NADPH oxidase are the main determinants of physical frailty in older adults
    Baptista, Gregory
    Dupuy, Anne-Marie
    Jaussent, Audrey
    Durant, Richard
    Ventura, Emilie
    Sauguet, Pauline
    Picot, Marie-Christine
    Jeandel, Claude
    Cristol, Jean Paul
    [J]. FREE RADICAL RESEARCH, 2012, 46 (09) : 1108 - 1114
  • [9] Immune-endocrine biomarkers as predictors of frailty and mortality: a 10-year longitudinal study in community-dwelling older people
    Baylis, D.
    Bartlett, D. B.
    Syddall, H. E.
    Ntani, G.
    Gale, C. R.
    Cooper, C.
    Lord, J. M.
    Sayer, A. A.
    [J]. AGE, 2013, 35 (03) : 963 - 971
  • [10] DNA methylation in repetitive elements and Alzheimer disease
    Bollati, V.
    Galimberti, D.
    Pergoli, L.
    Dalla Valle, E.
    Barretta, F.
    Cortini, F.
    Scarpini, E.
    Bertazzi, P. A.
    Baccarelli, A.
    [J]. BRAIN BEHAVIOR AND IMMUNITY, 2011, 25 (06) : 1078 - 1083
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