Oncogenic Role of Tumor Necrosis Factor α-Induced Protein 8 (TNFAIP8)

被引：47

作者：

Niture, Suryakant ^{[1
]}

Dong, Xialan ^{[2
]}

Arthur, Elena ^{[1
]}

Chimeh, Uchechukwu ^{[1
]}

Niture, Samiksha S. ^{[3
]}

Zheng, Weifan ^{[2
]}

Kumar, Deepak ^{[1
,4
]}

机构：

[1] North Carolina Cent Univ, Julius L Chambers Biomed Biotechnol Res Inst BBRI, Durham, NC 27707 USA

[2] North Carolina Cent Univ, Biomfg Res Inst & Technol Enterprise BRITE, Durham, NC 27707 USA

[3] Catonsville High Sch, Catonsville, MD 21228 USA

[4] North Carolina Cent Univ, Dept Pharmaceut Sci, Durham, NC 27707 USA

来源：

CELLS | 2019年 / 8卷 / 01期

基金：

美国国家卫生研究院;

关键词：

tumor necrosis factor alpha (TNF alpha); tumor necrosis factor alpha-inducing protein 8 (TNFAIP8); oncogene; autophagy; cell survival; SQUAMOUS-CELL CARCINOMA; DEATH EFFECTOR DOMAIN; NEGATIVE REGULATOR; POOR-PROGNOSIS; CANCER; TIPE2; EXPRESSION; OVEREXPRESSION; METASTASIS; APOPTOSIS;

D O I：

10.3390/cells8010009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Tumor necrosis factor (TNF)-alpha-induced protein 8 (TNFAIP8) is a founding member of the TIPE family, which also includes TNFAIP8-like 1 (TIPE1), TNFAIP8-like 2 (TIPE2), and TNFAIP8-like 3 (TIPE3) proteins. Expression of TNFAIP8 is strongly associated with the development of various cancers including cancer of the prostate, liver, lung, breast, colon, esophagus, ovary, cervix, pancreas, and others. In human cancers, TNFAIP8 promotes cell proliferation, invasion, metastasis, drug resistance, autophagy, and tumorigenesis by inhibition of cell apoptosis. In order to better understand the molecular aspects, biological functions, and potential roles of TNFAIP8 in carcinogenesis, in this review, we focused on the expression, regulation, structural aspects, modifications/interactions, and oncogenic role of TNFAIP8 proteins in human cancers.

引用

页数：16

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