REDOX STATUS IN WISTAR RAT BLOOD AFTER HYPDXIA

The regulation of tissue oxygen homeostasis is a fundamental and a defence parameter during hypoxia and represents a basic problem of the physical effort, life at altitude adaptation and neonatological pathology. The integration of the circulation and breathing mechanisms are already known, but the integrative mechanisms which regulate and control the amount of hemoglobin and the response to oxidative aggression are less clarified. In the present study we monitorized the blood antioxidant parameters in immature Wistar rats exposed to hypoxia. We measured the activity of the antioxidant enzymes (catalase - CAT, superoxide dismutase -SOD, glutahion peroxidase - GPx) and also transaminases (ALT, AST) and lactate dehidrogenase (LDH) as markers of cellular destruction.