Recent advances in erythrocyte membrane-camouflaged nanoparticles for the delivery of anti-cancer therapeutics

被引：14

作者：

Wang, Siyu ^{[1
]}

Wang, Yiwei ^{[2
]}

Jin, Kai ^{[1
]}

Zhang, Bo ^{[2
]}

Peng, Shaojun ^{[3
]}

Nayak, Amit Kumar ^{[4
]}

Pang, Zhiqing ^{[1
]}

机构：

[1] Fudan Univ, Sch Pharm, Key Lab Smart Drug Delivery, Minist Educ, 826 Zhangheng Rd, Shanghai 201203, Zhejiang, Peoples R China

[2] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Inst Hematol, Wuhan, Hubei, Peoples R China

[3] Jinan Univ, Zhuhai Peoples Hosp, Zhuhai Precis Med Ctr, Zhuhai Inst Translat Med,Zhuhai Hosp, Zhuhai 519000, Guangdong, Peoples R China

[4] Seemanta Inst Pharmaceut Sci, Dept Pharmaceut, Mayurbhanj, India

来源：

EXPERT OPINION ON DRUG DELIVERY | 2022年 / 19卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Erythrocyte membrane-camouflaged nanoparticles; biomimetic nanoparticles; cancer therapy; targeting drug delivery; pharmacokinetics; CONTROLLED DRUG-RELEASE; PHOTOTHERMAL THERAPY; POLYMERIC NANOPARTICLES; IN-VIVO; SURFACE FUNCTIONALIZATION; MELANIN NANOPARTICLES; PHOTODYNAMIC THERAPY; PROTEIN ADSORPTION; RBC MEMBRANES; CLEARANCE;

D O I：

10.1080/17425247.2022.2108786

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Introduction Red blood cell (or erythrocyte) membrane-camouflaged nanoparticles (RBC-NPs) not only have a superior circulation life and do not induce accelerated blood clearance but also possess special functions, which offers great potential in cancer therapy. Areas covered This review focuses on the recent advances of RBC-NPs for delivering various agents to treat cancers in light of their vital role in improving drug delivery. Meanwhile, the construction and in vivo behavior of RBC-NPs are discussed to provide an in-depth understanding of the basis of RBC-NPs for improved cancer drug delivery. Expert opinion Although RBC-NPs are quite prospective in delivering anti-cancer therapeutics, they are still in their infancy stage and many challenges need to be overcome for successful translation into the clinic. The preparation and modification of RBC membranes, the optimization of coating methods, the scale-up production and the quality control of RBC-NPs, and the drug loading and release should be carefully considered in the clinical translation of RBC-NPs for cancer therapy.

引用

页码：965 / 984

页数：20

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