Aptamers that bind to the antibiotic moenomycin A

被引：40
作者：
Schürer, H
Stembera, K
Knoll, D
Mayer, G
Blind, M
Förster, HH
Famulok, M
Welzel, P
Hahn, U
机构：
[1] Univ Bonn, Kekule Inst Organ Chem & Biochem, D-53121 Bonn, Germany
[2] Univ Leipzig, Inst Biochem, D-04103 Leipzig, Germany
[3] Univ Leipzig, Inst Organ Chem, D-04103 Leipzig, Germany
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2001年 / 9卷 / 10期
关键词：
D O I：
10.1016/S0968-0896(01)00030-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nuclease-resistant moenomycin-binding aptamers with dissociation constants in the range of 300 to 400 nM have been selected. Competition experiments have demonstrated that these aptamers recognize a disaccharide analogue of moenomycin. The results offer the opportunity of setting up a selective and sensitive assay for identifying moenomycin biosynthetic precursors. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2557 / 2563
页数：7
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