A role of sphingomyelin lipid circle components in. inflammation process coused by CCl4 at rats liposomes loaded by sphingomyelin or ceramide administed

Sphingolipids comprise indispensable structural components of all known eukaryotic plasma membranes they regulate the signal transduction elements including protein kinase C. Sphingosine, ceramide and other sphingolipid derivatives are also known to play central role in apoptosis, cell cycle regulation, inflammation and intracellular calcium mobilization. To get experimental inflammation of a rat liver the CCl4 was administered. During the process of experimental hepatitis development the liposomes loaded by the modulators of a sphingomyeline lipid cycle (SLC)-the, sphingomyelin and ceramide were administed. The components of a SLC change were tested by the contents of a sphingomyelin, ceramids. The increase in ceramides and decrease in spingomyelin contents at the rat's liver was revealed. Thus a result indicates the decrease in an inflammation process of a liver tissue. The morphological research of a liver tissue confirmed the reduction of hepatitis activity during the liposomes entered. The injects of liposomes loaded the SLC's modulators reduced the activity the inflammation process of liver tissue.