Is protein folding hierarchic? I. Local structure and peptide folding

被引:474
作者
Baldwin, RL [1 ]
Rose, GD
机构
[1] Stanford Univ, Med Ctr, Sch Med, Dept Biochem,Beckman Ctr, Stanford, CA 94305 USA
[2] Johns Hopkins Univ, Sch Med, Dept Biophys & Biophys Chem, Baltimore, MD 21205 USA
关键词
D O I
10.1016/S0968-0004(98)01346-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The folding reactions of some small proteins show clear evidence of a hierarchic process, whereas others, lacking detectable intermediates, do not. Nevertheless, we argue that both classes fold hierarchically and that folding begins locally. If this is the case, then the secondary structure of a protein is determined largely by local sequence information. Experimental data and theoretical considerations support this argument. Part I of this article reviews the relationship between secondary structures in proteins and their counterparts in peptides.
引用
收藏
页码:26 / 33
页数:8
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