Efficacy and safety of sofosbuvir-based triple therapy in hepatitis C genotype 4 infection

Background: There are only limited data on sofosbuvir-based treatment regimens in hepatitis C virus (HCV) genotype 4-infected patients. Aims: To evaluate safety and efficacy of sofosbuvir-based triple-therapy in HCV genotype 4 infection. Methods: All HCV genotype 4-infected patients who started sofosbuvir-based triple-therapy at our two centres between January and June 2014 were prospectively included (N = 24) and compared to genotype 4 patients treated with peginterferon/ribavirin between January 2001 and December 2012 (N = 63). Results: The demographics in the sofosbuvir group and the controls were comparable (males 87.5% and 82.5%; mean age 46.7 +/- 9.0 years and 42.0 +/- 9.8 years, respectively). Sustained virological response was achieved in 83.3% in the sofosbuvir group and in 47.6% of controls (P = 0.003). Fatigue (P = 0.007), flulike (P = 0.015), gastrointestinal (P < 0.001), dermatologic (P < 0.001) and psychiatric symptoms (P = 0.022) were more common in the control group. Conclusions: In our real-life cohort, sofosbuvir-based triple therapy confirmed its high efficacy and safety for chronic genotype 4 hepatitis C. (C) 2015 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.