Inclusion of a photosensitizer in liposomes formed by DMPC/Gemini surfactant: Correlation between physicochemical and biological features of the complexes

被引：68

作者：

Bombelli, C

Caracciolo, G

Di Profio, P

Diociaiuti, M

Luciani, P

Mancini, G

Mazzuca, C

Marra, M

Molinari, A

Monti, D

Toccacieli, L

Venanzi, M

机构：

[1] CNR, Ist Metodol Chim, Sez Meccan Reaz, I-00185 Rome, Italy

[2] Univ Roma La Sapienza, Dipartimento Chim, I-00185 Rome, Italy

[3] CEMIN, Ctr Eccellenza Mat Innovat Nanostrutt Appl Chim F, I-06123 Perugia, Italy

[4] Univ Perugia, Dipartimento Chim, I-06123 Perugia, Italy

[5] Ist Super Sanita, Dipartimento Tecnol & Salute, I-00161 Rome, Italy

[6] Univ Roma Tor Vergata, Dipartimento Sci & Tecnol Chim, I-00133 Rome, Italy

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2005年 / 48卷 / 15期

关键词：

D O I：

10.1021/jm050182d

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Mixed cationic liposomes composed by different ratios of dimyristoyl-sn-glycero-phosphatidylcoline (DMPC) and a cationic gemini surfactant have been studied by various physicochemical tools as vehicles for m-tetrahydroxyphenylchlorin (m-THPC), a photosensitizer used in photodynamic therapy. Entrapment and location of m-THPC within the lipid double layer have been evaluated by different techniques and the new formulations have been tested on a stabilized cell line from a human colon tumor, COLO206. A correlation between the physicochemical features of formulations and their efficiency as photosensitizers vector was found.

引用

页码：4882 / 4891

页数：10

共 6 条

[1] Influence of the stereochemistry of a gemini cationic surfactant on the biological features of liposomes
Bombelli, Cecilia
Borocci, Stefano
Bozzuto, Giuseppina
Colone, Marisa
Giansanti, Luisa
Mancini, Giovanna
Molinari, Agnese
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2010, 239
[2] How stereochemistry affects the physicochemical features of gemini surfactant based cationic liposomes
Aleandri, Simone
Bonicelli, Maria Grazia
Bordi, Federico
Casciardi, Stefano
Diociaiuti, Marco
Giansanti, Luisa
Leonelli, Francesca
Mancini, Giovanna
Perrone, Giuseppe
Sennato, Simona
SOFT MATTER, 2012, 8 (21) : 5904 - 5915
[3] Structurally related glucosylated liposomes: Correlation of physicochemical and biological features
Mauceri, Alessandro
Giansanti, Luisa
Bozzuto, Giuseppina
Condello, Maria
Molinari, Agnese
Galantini, Luciano
Piozzi, Antonella
Mancini, Giovanna
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2019, 1861 (08): : 1468 - 1475
[4] Inclusion complexes between β-cyclodextrin and a gemini surfactant in aqueous solution:: An NMR study
Guerrero-Martinez, Andres
Gonzalez-Gaitano, Gustavo
Vinas, Montserrat H.
Tardajos, Gloria
JOURNAL OF PHYSICAL CHEMISTRY B, 2006, 110 (28): : 13819 - 13828
[5] Physicochemical, molecular, and biological properties of complexes formed between aminoglycoside antibiotics and some anionic copolymers of acrylic series: Part II
Tarabukina, Elena B.
Solovskii, Mikhail V.
Pautov, Vladimir D.
Amirova, Alina I.
Zakharova, Natalia V.
Smirnova, Marianna Y.
Anan'eva, Tatiana D.
Imanbaev, Renat T.
Eropkin, Mikhail Y.
Eropkina, Elena M.
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, 2015, 30 (06) : 571 - 583
[6] Structural Features, Physicochemical Properties, and In Vitro Digestibility of the Starch-Lipid Complexes Formed between High Amylose Starch and Stearic Acid or Potassium Stearate
Zhai, Yuheng
Zhang, Hao
Sang, Shangyuan
Ren, Bin
Yuan, Yongjun
Xing, Jiali
Luo, Xiaohu
FOODS, 2024, 13 (06)

← 1 →