An Efficient Copper-Catalyzed Etherification of Aryl Halides

被引：32
|
作者：
Huang, Jinkun [1 ]
Chen, Ying [1 ]
Chan, Johann [1 ]
Ronk, Mike L. [1 ]
Larsen, Robert D. [1 ]
Faul, Margaret M. [1 ]
机构：
[1] Amgen Inc, Chem Proc R&D, Thousand Oaks, CA 91320 USA
来源：
SYNLETT | 2011年 / 10期
关键词：
ligand-free; copper; etherification; aryl halides; C-O; LIGAND-FREE; ULLMANN; ARYLATION; PHENOLS;
D O I：
10.1055/s-0030-1260761
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and mild copper-catalyzed ether formation from aryl halides and aliphatic alcohols has been developed. The key to the successful coupling is the use of lithium alkoxide, directly or in situ generated by lithium tert-butoxide, and the corresponding alcohol as solvent.
引用
收藏
页码：1419 / 1422
页数：4
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