Fatal adenovirus hepatitis during maintenance therapy for childhood acute lymphoblastic leukemia

被引：35

作者：

Steiner, Isabelle ^{[1
]}

Aebi, Christoph ^{[2
]}

Luethy, Annette Ridolfi ^{[1
]}

Wagner, Bendicht ^{[3
]}

Leibundgut, Kurt ^{[1
]}

机构：

[1] Univ Childrens Hosp, Div Pediat Hematol Oncol, Inselspital, CH-3010 Bern, Switzerland

[2] Univ Childrens Hosp, Inselspital, Div Pediat Infectiol, Bern, Switzerland

[3] Univ Childrens Hosp, Inselspital, Div Pediat Intes Care, Bern, Switzerland

来源：

PEDIATRIC BLOOD & CANCER | 2008年 / 50卷 / 03期

关键词：

acute lymphoblastic leukemia; adenovirus hepatitis; algorithm; chemotherapy;

D O I：

10.1002/pbc.21120

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Disseminated adenoviral infection with hepatitis is rare in children undergoing standard chemotherapy. We report on a 31/2-year-old male with fatal adenovirus hepatitis receiving maintenance chemotherapy for acute lymphoblastic leukemia (ALL). Adenoviral hepatitis was proven by histology, viral culture, and PCR in a liver biopsy. Quantitative real-time PCR in the peripheral blood showed adenoviral DNA copy number > 10(9)/ml. Despite aggressive supportive care and antiviral treatment with cidofovir, the patient died rapidly due to fulminant liver failure. Diagnostic and treatment options for adenovirus infection remain unsatisfactory for these patients. We propose Suggestions for diagnosis and therapy.

引用

页码：647 / 649

页数：3

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