Improved Quantification of Labeled LC-MS

被引：5

作者：

Chen, Long ^{[1
]}

Petritis, Konstantinos ^{[2
]}

Tegeler, Tony ^{[2
]}

Petritis, Brianne ^{[3
]}

Haskins, William E. ^{[4
]}

Zhang, Jianqiu ^{[1
]}

机构：

[1] Univ Texas San Antonio, Dept ECE, San Antonio, TX 78249 USA

[2] Translat Genom TGen Res Inst, Ctr Prote, Phoenix, AZ USA

[3] Arizona State Univ, Biodesign Inst, Tempe, AZ USA

[4] Univ Texas San Antonio, Dept Biol & Chem, San Antonio, TX USA

来源：

2011 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE (BIBM 2011) | 2011年

关键词：

LC-MS; Quantifiication; SILAC; O16/O18; MASS-SPECTROMETRY; QUANTITATIVE-ANALYSIS; PEPTIDES; PROTEOMICS; PROTEINS; RATIOS; TANDEM;

D O I：

10.1109/BIBM.2011.75

中图分类号：

TP39 [计算机的应用];

学科分类号：

081203 ; 0835 ;

摘要：

A novel quantification method is proposed for labeled LC-MS data. Unlike the traditional extracted ion chromatogram based quantification methods, the new method considers the reliability or the quality of signals with different intensities and applies more weights to the more reliable signals in the relative quantification procedure. Testing shows that the new method has improved accuracy than current quantification software.

引用

页码：299 / 303

页数：5

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