Origins of the 2009 H1N1 influenza pandemic in swine in Mexico

被引：215

作者：

Mena, Ignacio ^{[1
,2
]}

Nelson, Martha I. ^{[3
]}

Quezada-Monroy, Francisco ^{[4
]}

Dutta, Jayeeta ^{[5
]}

Cortes-Fernandez, Refugio ^{[4
]}

Horacio Lara-Puente, J. ^{[4
]}

Castro-Peralta, Felipa ^{[4
]}

Cunha, Luis F. ^{[1
,5
]}

Trovao, Nidia S. ^{[2
,3
,6
]}

Lozano-Dubernard, Bernardo ^{[4
]}

Rambaut, Andrew ^{[3
,7
,8
]}

van Bakel, Harm ^{[5
]}

Garcia-Sastre, Adolfo ^{[1
,2
,9
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Microbiol, New York, NY 10029 USA

[2] Icahn Sch Med Mt Sinai, Global Hlth & Emerging Pathogens Inst, New York, NY 10029 USA

[3] NIH, Div Int Epidemiol & Populat Studies, Fogarty Int Ctr, Bethesda, MD 20892 USA

[4] Lab Avi Mex, Mexico City, DF, Mexico

[5] Icahn Sch Med Mt Sinai, Genet & Genom Sci, New York, NY 10029 USA

[6] Univ Leuven, Rega Inst, Dept Microbiol & Immunol, Leuven, Belgium

[7] Univ Edinburgh, Inst Evolutionary Biol, Edinburgh, Midlothian, Scotland

[8] Univ Edinburgh, Ctr Immunol Infect & Evolut, Edinburgh, Midlothian, Scotland

[9] Icahn Sch Med Mt Sinai, Div Infect Dis, Dept Med, New York, NY 10029 USA

来源：

ELIFE | 2016年 / 5卷

基金：

美国国家卫生研究院;

关键词：

A VIRUSES; TRANSMISSION DYNAMICS; UNITED-STATES; EVOLUTION; ALIGNMENT; HEMAGGLUTININ; ESTABLISHMENT; REASSORTMENT; DIVERSITY; EXPANSION;

D O I：

10.7554/eLife.16777

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Asia is considered an important source of influenza A virus (IAV) pandemics, owing to large, diverse viral reservoirs in poultry and swine. However, the zoonotic origins of the 2009 A/H1N1 influenza pandemic virus (pdmH1N1) remain unclear, due to conflicting evidence from swine and humans. There is strong evidence that the first human outbreak of pdmH1N1 occurred in Mexico in early 2009. However, no related swine viruses have been detected in Mexico or any part of the Americas, and to date the most closely related ancestor viruses were identified in Asian swine. Here, we use 58 new whole-genome sequences from IAVs collected in Mexican swine to establish that the swine virus responsible for the 2009 pandemic evolved in central Mexico. This finding highlights how the 2009 pandemic arose from a region not considered a pandemic risk, owing to an expansion of IAV diversity in swine resulting from long-distance live swine trade.

引用

页数：21

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